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aNeuro Exam I- Lindsey's > ANS Pharm > Flashcards

Flashcards in ANS Pharm Deck (71):
1

The action potential reaches nerve terminal, allowing _____ entry into the cell, which leads to release of
neurotransmitter.

Ca++

2

The action potential reaches nerve terminal, allowing Ca++ entry into the cell, which leads to release of
______.

the neurotransmitter

3

What is an agonist?

a drug that mimicks the neurotransmitter action (generally at the receptor level)

4

This is a drug that mimicks the neurotransmitter action (generally at the receptor level).

an agonist

5

What is an antagonist?

a drug that blocks the neurotransmitter action (generally at the receptor level)

6

This is a drug that blocks the neurotransmitter action (generally at the receptor level).

an antagonist

7

The greatest selectivity of drug action is possible with drugs that act where?

post-synaptically

8

What are Cholinergic Agonists?

drugs that produce the same effect as acetylcholine at muscarinic cholinergic receptors on parasympathetic end organs (also known as parasympathomimetics or cholinomimetics)

9

These are drugs that produce the same effect as acetylcholine at muscarinic cholinergic receptors on parasympathetic end organs (also known as parasympathomimetics or cholinomimetics).

cholinergic agonists

10

What are Cholinergic Antagonists?

drugs that have direct action at cholinergic receptors to block effects of acetylcholine

11

These are drugs that have direct action at cholinergic receptors to block effects of acetylcholine.

cholinergic antagonists

12

What do drugs with indirect NT action do?

change the normal action of the NT

13

These are drugs that change the normal action of the NT.

indirect action NTs

14

How do indirect-action cholinergic agonists work?

they interact with some aspect of the synthesis-storage-release-inactivation of Ach to increase its synaptic levels and increase stim of the PNS

15

These drugs work by interacting with some aspect of the synthesis-storage-release-inactivatipn of Ach to increase its synaptic levels and increase stim of the PNS.

indirect-action cholinergic agonists

16

What do cholinergic antagonists do?

block effects of ACh

17

What is an adrenergic agonist?

a drug that produces the same effects as NE/Epi at adrenergic receptors on sympathetic end organs

18

How do adrenergic antagonists work?

they block the effects of NE/Epi at adrenergic synapses

19

These drugs block the effects of ACh.

cholinergic antagonists

20

These drugs block the effects of NE/Epi at adrenergic synapses.

adrenergic antagonists

21

This is a drug that produces the same effects as NE/Epi at adrenergic receptors on sympathetic end organs.

adrenergic agonists

22

What is hemicholinium?

it blocks choline active transport (prevents ACh synthesis)

23

This blocks choline active transport (prevents ACh synthesis).

hemicholinium

24

What is vesamicol?

it blocks ACh storage vesicles

25

This blocks ACh storage vesicles.

vesamicol

26

What blocks ACh release?

botulinum toxin

27

What increases ACh release?

black widow spider toxin

28

What kind of receptor is a nicotinic receptor?

a ligand-gated ion channel for ACh

29

What kind of receptor is a muscarinic receptor?

a GPCR for ACh

30

What kinds of drugs can enter the BBB?

lipid soluble tertiary agents (uncharged)

31

Name 2 direct-acting muscarinic receptor agonists.

ACh (not used)
Bethanechol (Urecholine)
Pilocarpine (Salagen)

32

What do all these drugs have in common?
ACh (not used)
Bethanechol (Urecholine)
Pilocarpine (Salagen)

they are direct-acting muscarinic receptor agonists

33

Name a direct acting nicotinic neuronal receptor agonist.

nicotine

34

Name 5 indirect-acting cholinesterase inhibitors.

Edrophonium
Neostigmine
Physostigmine
Isofluorophate
Organophosphate Nerve gas

35

What do all these drugs have in common?
Edrophonium
Neostigmine
Physostigmine
Isofluorophate
Organophosphate Nerve gas

they're all indirect-acting cholinesterase inhibitors (PNS)

36

Name 2 muscarinic cholinergic agonists.

pilocarpine
bethanechol

37

What do these 2 drugs have in common?
pilocarpine
bethanechol

they're both muscarinic cholinergic agonists

38

What is the effect of a ACh binding to muscarinic receptors (M2) in the heart?

decreased HR
decreased atrial contractility
decreased AV node conduction

39

What kind of cholinergic receptor is found on the heart?

M

40

What kinds of PNS receptors are found in the heart?

M

41

What one event can cause all these effects:
decreased HR
decreased atrial contractility
decreased AV node conduction

binding of ACh to a muscarinic receptor in the heart

42

What kinds of NT receptors are found in the heart?

M, β1

43

What kind of adrenergic receptor is found in the heart?

β1

44

What is the effect of NE/Epi binding to a β1 receptor in the heart?

increased HR
increased contractility

45

What is the effect of NE/Epi binding to a β2 receptor in the GI tract?

decreased motility

46

What is the effect of NE/Epi binding to a β1 receptor in the kidney?

increased renin secretion

47

Where are β1 receptors found?

heart
kidneys

48

Where are α1 receptors found?

eyes
BVs
GI tract/glands
urogenital tract

49

Where are β2 receptors found?

GI tract
urogenital system
BVs

50

Where are M receptors found?

eye
heart
airway/lungs
GI tracts/glands

51

Where are Nn receptors found?

adrenal medulla

52

Name 3 types of adrenergic receptors.

α1
β1
β2

53

What is the effect of a ACh binding to muscarinic receptors in the eyes?

miosis
accommodation of the eye

54

Binding of what NT to which receptor causes the following effects?
miosis
accommodation of the eye

ACh binding to muscarinic receptors in the eye

55

What is the effect of a ACh binding to muscarinic receptors in the airway/lungs?

constriction
increased secretions

56

Binding of what NT to which receptor causes the following effects?
airway constriction
increased secretions

ACh binding to muscarinic receptors in the lungs

57

Binding of what NT to which receptor causes the following effects?
erection
contraction of detrusor
relaxation of trigone and sphincters

ACh binding to muscarinic receptors in the urogenital system

58

What are the effects of ACh binding to muscarinic receptors in the urogenital system?

erection
contraction of detrusor
relaxation of trigone and sphincters

59

What are the effects of ACh binding to muscarinic receptors in the GI tract?

increased motility
increased secretions

60

Binding of what NT to which receptor causes the following effects?
increased motility
increased secretions

ACh binding to muscarinic receptors in the GI tract

61

What are the effects of Epi/NE binding to α1
receptors in the GI tract?

contraction of sphincters

62

What are the effects of Epi/NE binding to α1
receptors in the BVs?

constriction

63

What are the effects of Epi/NE binding to α1
receptors in the urogenital system?

ejaculation
contraction of trigone and sphincter

64

What NT binds to which receptor to cause BV constriction?

Epi/NE binding to α1 receptors

65

What NT binds to which receptor to cause the following effects?
ejaculation
contraction of trigone and sphincter

Epi/NE binding to α1
receptors in the urogenital system

66

What are the effects of Epi/NE binding to β2
receptors in the GI tract?

decreased motility

67

What are the effects of Epi/NE binding to β2
receptors in the urogenital system?

uterine relaxation
detrusor relaxation

68

What are the effects of Epi/NE binding to β2 receptors in the blood vessels?

dilation (skeletal muscle)

69

What NT binding to which receptor causes dilation of BVs (skeletal muscle)?

Epi/NE binding to β2 receptors

70

What NT binding to which receptor causes decreased GI motility?

Epi/NE binding to β2 receptors

71

What NT binding to which receptor causes the following effects?
uterine relaxation
detrusor relaxation

Epi/NE binding to β2 receptors