Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

aNeuro Exam I- Lindsey's > ANS Pharm > Flashcards

ANS Pharm Flashcards

(71 cards)

Start Studying
1
Q

The action potential reaches nerve terminal, allowing _____ entry into the cell, which leads to release of
neurotransmitter.

A

Ca++

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The action potential reaches nerve terminal, allowing Ca++ entry into the cell, which leads to release of
______.

A

the neurotransmitter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is an agonist?

A

a drug that mimicks the neurotransmitter action (generally at the receptor level)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

This is a drug that mimicks the neurotransmitter action (generally at the receptor level).

A

an agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is an antagonist?

A

a drug that blocks the neurotransmitter action (generally at the receptor level)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

This is a drug that blocks the neurotransmitter action (generally at the receptor level).

A

an antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The greatest selectivity of drug action is possible with drugs that act where?

A

post-synaptically

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are Cholinergic Agonists?

A

drugs that produce the same effect as acetylcholine at muscarinic cholinergic receptors on parasympathetic end organs (also known as parasympathomimetics or cholinomimetics)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

These are drugs that produce the same effect as acetylcholine at muscarinic cholinergic receptors on parasympathetic end organs (also known as parasympathomimetics or cholinomimetics).

A

cholinergic agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are Cholinergic Antagonists?

A

drugs that have direct action at cholinergic receptors to block effects of acetylcholine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

These are drugs that have direct action at cholinergic receptors to block effects of acetylcholine.

A

cholinergic antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What do drugs with indirect NT action do?

A

change the normal action of the NT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

These are drugs that change the normal action of the NT.

A

indirect action NTs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How do indirect-action cholinergic agonists work?

A

they interact with some aspect of the synthesis-storage-release-inactivation of Ach to increase its synaptic levels and increase stim of the PNS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

These drugs work by interacting with some aspect of the synthesis-storage-release-inactivatipn of Ach to increase its synaptic levels and increase stim of the PNS.

A

indirect-action cholinergic agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What do cholinergic antagonists do?

A

block effects of ACh

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is an adrenergic agonist?

A

a drug that produces the same effects as NE/Epi at adrenergic receptors on sympathetic end organs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How do adrenergic antagonists work?

A

they block the effects of NE/Epi at adrenergic synapses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

These drugs block the effects of ACh.

A

cholinergic antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

These drugs block the effects of NE/Epi at adrenergic synapses.

A

adrenergic antagonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

This is a drug that produces the same effects as NE/Epi at adrenergic receptors on sympathetic end organs.

A

adrenergic agonists

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What is hemicholinium?

A

it blocks choline active transport (prevents ACh synthesis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

This blocks choline active transport (prevents ACh synthesis).

A

hemicholinium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is vesamicol?

A

it blocks ACh storage vesicles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
This blocks ACh storage vesicles.
vesamicol
26
What blocks ACh release?
botulinum toxin
27
What increases ACh release?
black widow spider toxin
28
What kind of receptor is a nicotinic receptor?
a ligand-gated ion channel for ACh
29
What kind of receptor is a muscarinic receptor?
a GPCR for ACh
30
What kinds of drugs can enter the BBB?
lipid soluble tertiary agents (uncharged)
31
Name 2 direct-acting muscarinic receptor agonists.
ACh (not used) Bethanechol (Urecholine) Pilocarpine (Salagen)
32
What do all these drugs have in common? ACh (not used) Bethanechol (Urecholine) Pilocarpine (Salagen)
they are direct-acting muscarinic receptor agonists
33
Name a direct acting nicotinic neuronal receptor agonist.
nicotine
34
Name 5 indirect-acting cholinesterase inhibitors.
``` Edrophonium Neostigmine Physostigmine Isofluorophate Organophosphate Nerve gas ```
35
``` What do all these drugs have in common? Edrophonium Neostigmine Physostigmine Isofluorophate Organophosphate Nerve gas ```
they're all indirect-acting cholinesterase inhibitors (PNS)
36
Name 2 muscarinic cholinergic agonists.
pilocarpine | bethanechol
37
What do these 2 drugs have in common? pilocarpine bethanechol
they're both muscarinic cholinergic agonists
38
What is the effect of a ACh binding to muscarinic receptors (M2) in the heart?
decreased HR decreased atrial contractility decreased AV node conduction
39
What kind of cholinergic receptor is found on the heart?
M
40
What kinds of PNS receptors are found in the heart?
M
41
What one event can cause all these effects: decreased HR decreased atrial contractility decreased AV node conduction
binding of ACh to a muscarinic receptor in the heart
42
What kinds of NT receptors are found in the heart?
M, β1
43
What kind of adrenergic receptor is found in the heart?
β1
44
What is the effect of NE/Epi binding to a β1 receptor in the heart?
increased HR | increased contractility
45
What is the effect of NE/Epi binding to a β2 receptor in the GI tract?
decreased motility
46
What is the effect of NE/Epi binding to a β1 receptor in the kidney?
increased renin secretion
47
Where are β1 receptors found?
heart | kidneys
48
Where are α1 receptors found?
eyes BVs GI tract/glands urogenital tract
49
Where are β2 receptors found?
GI tract urogenital system BVs
50
Where are M receptors found?
eye heart airway/lungs GI tracts/glands
51
Where are Nn receptors found?
adrenal medulla
52
Name 3 types of adrenergic receptors.
α1 β1 β2
53
What is the effect of a ACh binding to muscarinic receptors in the eyes?
miosis | accommodation of the eye
54
Binding of what NT to which receptor causes the following effects? miosis accommodation of the eye
ACh binding to muscarinic receptors in the eye
55
What is the effect of a ACh binding to muscarinic receptors in the airway/lungs?
constriction | increased secretions
56
Binding of what NT to which receptor causes the following effects? airway constriction increased secretions
ACh binding to muscarinic receptors in the lungs
57
Binding of what NT to which receptor causes the following effects? erection contraction of detrusor relaxation of trigone and sphincters
ACh binding to muscarinic receptors in the urogenital system
58
What are the effects of ACh binding to muscarinic receptors in the urogenital system?
erection contraction of detrusor relaxation of trigone and sphincters
59
What are the effects of ACh binding to muscarinic receptors in the GI tract?
increased motility | increased secretions
60
Binding of what NT to which receptor causes the following effects? increased motility increased secretions
ACh binding to muscarinic receptors in the GI tract
61
What are the effects of Epi/NE binding to α1 | receptors in the GI tract?
contraction of sphincters
62
What are the effects of Epi/NE binding to α1 | receptors in the BVs?
constriction
63
What are the effects of Epi/NE binding to α1 | receptors in the urogenital system?
ejaculation | contraction of trigone and sphincter
64
What NT binds to which receptor to cause BV constriction?
Epi/NE binding to α1 receptors
65
What NT binds to which receptor to cause the following effects? ejaculation contraction of trigone and sphincter
Epi/NE binding to α1 | receptors in the urogenital system
66
What are the effects of Epi/NE binding to β2 | receptors in the GI tract?
decreased motility
67
What are the effects of Epi/NE binding to β2 | receptors in the urogenital system?
uterine relaxation | detrusor relaxation
68
What are the effects of Epi/NE binding to β2 receptors in the blood vessels?
dilation (skeletal muscle)
69
What NT binding to which receptor causes dilation of BVs (skeletal muscle)?
Epi/NE binding to β2 receptors
70
What NT binding to which receptor causes decreased GI motility?
Epi/NE binding to β2 receptors
71
What NT binding to which receptor causes the following effects? uterine relaxation detrusor relaxation
Epi/NE binding to β2 receptors

aNeuro Exam I- Lindsey's (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions