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Flashcards in Rotation: Pharm Deck (43):
1

D1-D2 direct agonist plus indirect agonist (releaser)

dopamine

2

Name 2 nicotinic receptor agonists.

  1. ACh
  2. nicotine

3

Name the SNS and PNS receptors in the GI/GU.

M α1 β2

4

Adrenergic Agonist; α 1, α2, β1

NE

5

Pralidoxime

cholinesterase reactivator (antidote for organophosphate poisoning)

6

Name the SNS and PNS receptors in the kidneys.

β1

7

1. List the precursors and key enzymes for the synthesis and transporters involved in the storage of acetylcholine and NE.

  • ACh synthesis= via choline acetyltransferase
  • storage = vesicular monoamine transporter (VMAT)
  • release = decreased by botox, increased by black widow spider toxin
  • termination = AChE
  • NE synthesis = via tyrosine hydroxylase
  • storage = vesicular monoamine transporter (VMAT)
  • release = VSCC
  • termination = MAO

8

Pilocarpine

muscarinic receptor agonist

9

Name the SNS and PNS receptors in the BVs.

M (not innervated) α1 β2

10

Adrenergic Agonist; α 1, α2, β1, β2 (nonselective)

epinephrine

11

Name the SNS and PNS receptors in the adrenal medulla.

Nn

12

Dopamine

D1-D2 direct agonist plus indirect agonist (releaser)

13

Physostigmine

AChE Inhibitor

14

Botulinum toxin

inhibits ACh release

15

Nicotine

nicotinic receptor agonist

16

2. Describe the synaptic mechanisms by which acetylcholine and NE are inactivated at a synapse.

  • diffusion
  • reuptake
  • destruction (AChE)

17

Name a Muscarinic Receptor Antagonist.

atropine

18

This inhibits acetylcholine release.

botulinum toxin

19

What is the antidote to SLUDGE s/s?

atropine

20

3. Describe the receptors and signal transduction systems for acetylcholine and NE.

  • ACh = ionotropic or metabotropic receptors
  • NE = GPCRs

21

Bethanechol

muscarinic receptor agonist

22

Name an NMJ depolarizing blocker.

succinylcholine

23

This is the antidote for organophosphate poisoning.

Pralidoxime

24

Edrophonium

AChE Inhibitor

25

Name the SNS and PNS receptors in the lungs.

M β2

26

Norepinephrine

Adrenergic Agonist; α1, α2, β1

27

What does SLUDGE mean, and what does it stand for?

adverse reactions to direct-acting muscarinic receptor drugs

S = salivation

L = lacrimation

U = urination

D = defication

G = GI (cramping, emesis, nausea)

E = eye (miosis)

28

Atacurium

NMJ competitive blocker (non-depolarizing) (-curare)

29

Name 3 muscarinic receptor agonists.

  1. ACh
  2. Bethanechol
  3. Pilocarpine

30

Succinylcholine

NMJ depolarizing blocker

31

What are the anticholinergic/antimuscarinic side effects?

no pee, no see, no spit, no shit

32

Name 4 AChE inhibitors.

  1. Physostigmine
  2. Neostigmine
  3. Edrophonium
  4. Organophosphates

33

Neostigmine

AChE Inhibitor

34

Name the SNS and PNS receptors in the eyes.

M α1

35

Epinephrine

Adrenergic Agonist; α1, α2, β1, β2 (nonselective)

36

Name 2 NMJ competitive blocker (non-depolarizing).

Atacurium; Rocuronium

37

Name the SNS and PNS receptors in the heart.

M β1

38

Name a cholinesterase inhibitor. What is it used for?

Pralidoxime; antidote for organophosphate poisoning

39

Acetylcholine

muscarinic receptor agonist

40

Acetylcholine

nicotinic receptor agonist

41

Rocuronium

NMJ competitive blocker (non-depolarizing) (-curare)

42

Organophosphates

AChE Inhibitor

43

Atropine

Muscarinic Receptor Antagonist