Rotation: Pharm

Question 1

D1-D2 direct agonist plus indirect agonist (releaser)

Answer 1

dopamine

Question 2

Name 2 nicotinic receptor agonists.

Answer 2

1. ACh
2. nicotine

Question 3

Name the SNS and PNS receptors in the GI/GU.

Answer 3

M α1 β2

Question 4

Adrenergic Agonist; α 1, α2, β1

Answer 4

NE

Question 5

Pralidoxime

Answer 5

cholinesterase reactivator (antidote for organophosphate poisoning)

Question 6

Name the SNS and PNS receptors in the kidneys.

Answer 6

β1

Question 7

1. List the precursors and key enzymes for the synthesis and transporters involved in the storage of acetylcholine and NE.

Answer 7

• ACh synthesis= via choline acetyltransferase
• storage = vesicular monoamine transporter (VMAT)
• release = decreased by botox, increased by black widow spider toxin
• termination = AChE
• NE synthesis = via tyrosine hydroxylase
• storage = vesicular monoamine transporter (VMAT)
• release = VSCC
• termination = MAO

Question 8

Pilocarpine

Answer 8

muscarinic receptor agonist

Question 9

Name the SNS and PNS receptors in the BVs.

Answer 9

M (not innervated) α1 β2

Question 10

Adrenergic Agonist; α 1, α2, β1, β2 (nonselective)

Answer 10

epinephrine

Question 11

Name the SNS and PNS receptors in the adrenal medulla.

Answer 11

Nn

Question 12

Dopamine

Answer 12

D1-D2 direct agonist plus indirect agonist (releaser)

Question 13

Physostigmine

Answer 13

AChE Inhibitor

Question 14

Botulinum toxin

Answer 14

inhibits ACh release

Question 15

Nicotine

Answer 15

nicotinic receptor agonist

Question 16

2. Describe the synaptic mechanisms by which acetylcholine and NE are inactivated at a synapse.

Answer 16

• diffusion
• reuptake
• destruction (AChE)

Question 17

Name a Muscarinic Receptor Antagonist.

Answer 17

atropine

Question 18

This inhibits acetylcholine release.

Answer 18

botulinum toxin

Question 19

What is the antidote to SLUDGE s/s?

Answer 19

atropine

Question 20

3. Describe the receptors and signal transduction systems for acetylcholine and NE.

Answer 20

• ACh = ionotropic or metabotropic receptors
• NE = GPCRs

Question 21

Bethanechol

Answer 21

muscarinic receptor agonist

Question 22

Name an NMJ depolarizing blocker.

Answer 22

succinylcholine

Question 23

This is the antidote for organophosphate poisoning.

Answer 23

Pralidoxime

Question 24

Edrophonium

Answer 24

AChE Inhibitor

Question 25

Name the SNS and PNS receptors in the lungs.

Answer 25

M β2

Question 26

Norepinephrine

Answer 26

Adrenergic Agonist; α1, α2, β1

Question 27

What does SLUDGE mean, and what does it stand for?

Answer 27

adverse reactions to direct-acting muscarinic receptor drugs S = salivation L = lacrimation U = urination D = defication G = GI (cramping, emesis, nausea) E = eye (miosis)

Question 28

Atacurium

Answer 28

NMJ competitive blocker (non-depolarizing) (-curare)

Question 29

Name 3 muscarinic receptor agonists.

Answer 29

1. ACh 2. Bethanechol 3. Pilocarpine

Question 30

Succinylcholine

Answer 30

NMJ depolarizing blocker

Question 31

What are the anticholinergic/antimuscarinic side effects?

Answer 31

no pee, no see, no spit, no shit

Question 32

Name 4 AChE inhibitors.

Answer 32

1. Physostigmine 2. Neostigmine 3. Edrophonium 4. Organophosphates

Question 33

Neostigmine

Answer 33

AChE Inhibitor

Question 34

Name the SNS and PNS receptors in the eyes.

Answer 34

M α1

Question 35

Epinephrine

Answer 35

Adrenergic Agonist; α1, α2, β1, β2 (nonselective)

Question 36

Name 2 NMJ competitive blocker (non-depolarizing).

Answer 36

Atacurium; Rocuronium

Question 37

Name the SNS and PNS receptors in the heart.

Answer 37

M β1

Question 38

Name a cholinesterase inhibitor. What is it used for?

Answer 38

Pralidoxime; antidote for organophosphate poisoning

Question 39

Acetylcholine

Answer 39

muscarinic receptor agonist

Question 40

Acetylcholine

Answer 40

nicotinic receptor agonist

Question 41

Rocuronium

Answer 41

NMJ competitive blocker (non-depolarizing) (-curare)

Question 42

Organophosphates

Answer 42

AChE Inhibitor

Question 43

Atropine

Answer 43

Muscarinic Receptor Antagonist