Anti-coagulants + Anti-platelet Drugs

Question 1

What is the antidote for heparin?

Answer 1

protamine sulphate

Question 2

What is the prototype for LMWHs?

Answer 2

Enoxaparin

Question 3

Do LMWHs require lab monitoring?

Answer 3

no

Question 4

Warfarin is strongly contraindicated in?

Answer 4

pregnancy

Question 5

Anticoagulants are used?

Answer 5

prophylactically to prevent clots

Question 6

How does Wafarin work?

Answer 6

it is a vitamin K antagonist and it will cause the liver to make less clotting factors.

Question 7

Wafarin sodium is given _____ only

Answer 7

orally

Question 8

The effects of warfarin may take up to?

Answer 8

3-5 days

Question 9

Heparin acts?

Answer 9

immediately

Question 10

Warfarin is monitored by?

Answer 10

prothrombin time

Question 11

INR

Answer 11

used to monitor warfarin and corrects lab-to-lab variability

Question 12

INR too high = ?

Answer 12

reduce dose

Question 13

PT must be _____ the normal (control level)?

Answer 13

1.3 to 1.5 times

Question 14

Normal target INR range is ____ control?

Answer 14

2-3 times the control

Question 15

what is a food-drug interaction of warfarin?

Answer 15

food that contain Vitamin K

Question 16

What is the best way to achieve a consistent effect of warfarin?

Answer 16

Keep vitamin K levels constant

Question 17

What is the prototype for direct thrombin inhibitors?

Answer 17

Dabigatran

Question 18

What is the prototype of direct factor Xa inhibitors?

Answer 18

rivaroxaban

Question 19

what is the greatest adverse effects of ALL anticoagulants?

Answer 19

Increased risk of bleeding

Question 20

What are the 2 examples of anti platelet drugs?

Answer 20

ASA and clopidogrel

Question 21

clopidogrel is an irreversible…?

Answer 21

ADP receptor blocker

Question 22

Antiplatelet agents are used to?

Answer 22

prevent clots

Question 23

What is the lowest effective dose of ASA for anti platelet effects?

Answer 23

81 mg per day

Question 24

Aspirin + clopidogrel combination…?

Answer 24

produces additive anti platelet activity BUT causes increased bleeding potential.

Question 25

Heparin acts on the ______ pathway

Answer 25

intrinsic

Question 26

How is Heparin monitored?

Answer 26

by activated partial thromboplastin times (aPTT)

Question 27

aPTT is a measure of the?

Answer 27

intrinsic pathway

Question 28

aPTTs need to be _______ greater than the control?

Answer 28

1.5 to 2.5 times