Antifungal drugs

Question 1

polyenes

Answer 1

naturally occurring antifungals

Question 2

Azoles

Answer 2

synthetic antifungals

Question 3

amphotericin B is a

Answer 3

polyene

Question 4

drug of choice for systemic mycoses

Answer 4

amphotericin B

Question 5

Amphotericin B is used only in infections that are

Answer 5

progressive and potentially fatal

Question 6

Amphotericin B is administered by

Answer 6

Slow IV infusion

Question 7

Mechanism of amphotericin B

Answer 7

increases cell membrane permeability causing leakage of intracellular cations. Binds to sterols and makes holes in the membrane

Question 8

Higher concentrations of amphotericin B causes

Answer 8

drug will bind to cholesterol in human cells and cause toxicities

Question 9

Nystatin is a

Answer 9

polyene

Question 10

nystatin is used for

Answer 10

superficial infections

Question 11

Mechanism of azoles

Answer 11

inhibits sterol-altering enzyme therefore inhibiting ergosterol synthesis. inhibits growth of fungi.

Question 12

main concerns of amphotericin B

Answer 12

1. renal toxicity
2. hypoalkemia
3. impairs hepatic function

Question 13

Does renal toxicity mean you will have to stop treatment with amphotericin B

Answer 13

No, continue treatment because the patient will die if they have a systemic fungal infection.

Question 14

Azoles inhibit

Answer 14

hepatic CYP enzymes causing competition when other drugs are administered. Higher levels of one drug will occur.