Cholinergic Drugs

Question 1

Drug effects of cholinesterase inhibitors?

Answer 1

SLUDGE: Salivation, Lacrimation, Urinary incontinence, Diarrhea, GI cramps, emesis

Question 2

Cholinesterase inhibitors are used to treat?

Answer 2

Alzheimers disease

Question 3

What is an example of a cholinesterase inhibitor used to treat Alzheimers disease?

Answer 3

Donepezil

Question 4

what so cholinesterase inhibitors do?

Answer 4

they stop the breakdown of ACh

Question 5

what is an example of a direct acting cholinergic agonist used to treat glaucoma?

Answer 5

Pilocarpine

Question 6

what is an example of a direct acting cholinergic agonist used to aid bladder emptying?

Answer 6

Bethanechol

Question 7

how does pilocarpine treat glaucoma ?

Answer 7

it reduces intraocular pressure

Question 8

what is the route of administration for pilocarpine?

Answer 8

topical, due to poor oral absorption

Question 9

how does bethanechol aid bladder emptying?

Answer 9

it helps increase tone and motility of the bladder and GI tract

Question 10

after taking bethanechol, urination should occur?

Answer 10

within 60 mins

Question 11

what is an adverse effect of all cholinergic agonists?

Answer 11

bradycardia

Question 12

what is the antidote for cholinergic stimulation?

Answer 12

atropine

Question 13

what is a major drug effect of muscarinic antagonists?

Answer 13

large doses cause increased HR

Question 14

Indication of atropine?

Answer 14

used pre and post operatively to reduce anesthesia induced bradycardia

Question 15

What is the antidote for atropine OD?

Answer 15

physostigmine

Question 16

therapeutic effects of donepezil may not occur for?

Answer 16

up to 6 weeks