Flashcards in Anti-Hypertensives Deck (147)
When is an antihypertensive indicated?
Sustained systolic BP over 140
Sustained diastolic BP over 90
Why is hypertension a "silent killer"?
Pts are asymptomatic, and heart is struggling. It eventually thickens and causes further problems
What two things control arterial blood pressure?
What are the 7 antihypertensive drug subclasses?
Angiotensin II receptor blockers
Ca Channel blockers
Name 5 ACE inhibitors
What is the common suffice for ACE-inhibitors?
What is the MOA of lisinopril?
How does an ACE-inhibitor act on the body?
Suppresses RAA system and simultaneously inhibits bradykinin degradation
What are the common adverse effects of lisinopril (ACE-inhibitors)
What are the distinguishing adverse effects of ACE-inhibitors?
What are the serious adverse hypersensitivity effects of Lisinopril?
What are the serious ocular adverse effects of Lisinopril?
Conjunctival or retinal hemes
ACE-inhibitors have important interactions with which two drugs?
What does the interaction of Lisinopril and Acetaminophen do?
Inhibits renal prostaglandins and antagonizes the therapy
What does the interaction of ACE-inhibitors and Cyclosporin do?
Induces renal toxicity causing hyperkalemia created by suppressed aldosterone release from the adrenal cortex
Lisinopril has one disease in which caution is required. Which disease is it?
The suffix -sartan belongs to what group of drugs?
Angiotensin II receptor blockers - for HTN
What are the two angiotensin II receptor blockers?
What are the indications for an angioensin II receptor blocker?
Congestive heart failure
Post myocardial infarction
What is the MOA for an ARB?
Selective antagonist of angiotensin II receptor
What are the common adverse effects of Valsartan?
What are the hypersensitivity reactions of ARBs?
What are the two drugs that have important interactions with Valsartan?
What happens when Valsartan interacts with NSAIDs?
What happens when ARBs interact with Cyclosporin?
What is hyperkalemia?
High blood potassium
What does hyperkalemia do to the body?
Can cause abnormal heart rhythms and even heart attack
What is the one disease that ACE-inhibitors don't help?
What is the most common drug for HTN?
ACE-inhibitors because it helps so many concomitant disease factors, as well