Anti-Hypertensives Flashcards Preview

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Flashcards in Anti-Hypertensives Deck (147)
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1

When is an antihypertensive indicated?

Sustained systolic BP over 140
Sustained diastolic BP over 90

2

Why is hypertension a "silent killer"?

Pts are asymptomatic, and heart is struggling. It eventually thickens and causes further problems

3

What two things control arterial blood pressure?

Cardiac Output
Peripheral resistance

4

What are the 7 antihypertensive drug subclasses?

ACE-inhibitors
Angiotensin II receptor blockers
Ca Channel blockers
Alpha-blockers
Beta-blockers
Diuretics
Other

5

Name 5 ACE inhibitors

Lisinopril
Benazepril
Captopril
Enalapril
Quinapril

6

What is the common suffice for ACE-inhibitors?

-pril

7

What is the MOA of lisinopril?

ACE-inhibitor

8

How does an ACE-inhibitor act on the body?

Suppresses RAA system and simultaneously inhibits bradykinin degradation

9

What are the common adverse effects of lisinopril (ACE-inhibitors)

Photophobia
Reduced vision
Headache
Hypotension
Conjunctivitis

10

What are the distinguishing adverse effects of ACE-inhibitors?

Cough
Taste disturbances

11

What are the serious adverse hypersensitivity effects of Lisinopril?

Angioedema
Eyelid edema

12

What are the serious ocular adverse effects of Lisinopril?

Blur
Dry eye
Conjunctival or retinal hemes
Diplopia

13

ACE-inhibitors have important interactions with which two drugs?

Acetaminophen
Cyclosporin

14

What does the interaction of Lisinopril and Acetaminophen do?

Inhibits renal prostaglandins and antagonizes the therapy

15

What does the interaction of ACE-inhibitors and Cyclosporin do?

Induces renal toxicity causing hyperkalemia created by suppressed aldosterone release from the adrenal cortex

16

Lisinopril has one disease in which caution is required. Which disease is it?

Sjogren's syndrome

17

The suffix -sartan belongs to what group of drugs?

Angiotensin II receptor blockers - for HTN

18

What are the two angiotensin II receptor blockers?

Valsartan
Condesartan

19

What are the indications for an angioensin II receptor blocker?

HTN
Congestive heart failure
Post myocardial infarction

20

What is the MOA for an ARB?

Selective antagonist of angiotensin II receptor

21

What are the common adverse effects of Valsartan?

Headache
Dizziness

22

What are the hypersensitivity reactions of ARBs?

Angioedema
Vasculitis

23

What are the two drugs that have important interactions with Valsartan?

NSAIDs
Cyclosporine

24

What happens when Valsartan interacts with NSAIDs?

Antagonism

25

What happens when ARBs interact with Cyclosporin?

Hyperkalemia

26

What is hyperkalemia?

High blood potassium

27

What does hyperkalemia do to the body?

Can cause abnormal heart rhythms and even heart attack

28

What is the one disease that ACE-inhibitors don't help?

Angina

29

What is the most common drug for HTN?

ACE-inhibitors because it helps so many concomitant disease factors, as well

30

Why is it believe that patients on ACE-inhibitors develop a cough?

Bradykinin accumulation