Flashcards in Dyslipidemia Deck (33)
What are the 4 types of lipid lowering therapeutics?
HMG CoA Reductase inhibitors
Cholesterol Absorption inhibitors
What are the normal and borderline numbers for total cholesterol?
What are the normal and borderline numbers for LDL cholesterol?
What are the normal and borderline numbers for HDL cholesterol?
Normal: > 60
What class of lipid lowering drug is Atrovastatin?
HMG CoA reductase inhibitor (statin)
What are the 2 indications for Atrovastatin?
What is the MOA of Atrovastatin?
Inhibits HMG-CoA reductase
Increases hepatic LDL receptors, enhancing catabolism
What is HMG-CoA reductase responsible for?
An early, rate-limiting step in cholesterol biosynthesis
What are the 5 common adverse effects of Atrovastatin?
Impaired hepatic function associated with elevated serum transaminase levels
What are the 7 potential ocular side effects of Atrovastatin?
What is the 1 contraindicated drug for Atrovastatin?
Which drugs interact with Atrovastatin to cause myopathy exacerbation?
What class of lipid lowering drug is Fenofibrate?
What are the 3 indications for Fenofibrate?
Combo with statins, or for statin intolerant patients
What is the MOA of Fenofibrate?
Stimulates nuclear receptor PPAR, which modulates transcription of insulin sensitive genes in liver, muscle, and adipose tissue
Enhances HDL production, inhibits triglyceride synthesis
What are the 3 common side effects of Fenofibrate?
What are the 7 serious side effects of Fenofibrate?
Hypersensitivity: SJS, TEN
Hepatic: Hepatitis, Cirrhosis
Muscular: Myositis, myopathy, rhabdo
Which drugs interact with Fenofibrate to impair renal elimination?
Which drug interacts with Fenofibrate to cause impaired metabolism?
What are the 3 indications for Niacin?
What is the MOA of Niacin in dislypidemia?
Inhibits lipolysis in adipose tissue, resulting in reduced hepatic VLDL synthesis and production of LDLs in the plasma
Niacin is the most effective agent for increasing what?
What are the 9 common adverse effects of Niacin?
What are the 2 serious adverse effects of Niacin?
What does niacin induce that causes flushing and/or Mueller cell toxicity?
Prostaglandin D2 production
What drugs interact with Niacin to cause an additive effect?
Alpha and Beta blockers
Cautions need to be taken when Rxing Niacin with what two conditions?
Diabetes - elevates sugar
Surgery - anti-platelet effects
What class of dyslipidemia drug is Ezetimibe?
Cholesterol Absorption Inhibitor
What is the MOA of ezetimibe?
Inhibits dietary and biliary cholesterol absorption as the small intestine brush border