Dyslipidemia Flashcards Preview

Systemic Pharm > Dyslipidemia > Flashcards

Flashcards in Dyslipidemia Deck (33)
Loading flashcards...
1

What are the 4 types of lipid lowering therapeutics?

HMG CoA Reductase inhibitors
Fibrates
Niacin
Cholesterol Absorption inhibitors

2

What are the normal and borderline numbers for total cholesterol?

Normal:

3

What are the normal and borderline numbers for LDL cholesterol?

Normal:

4

What are the normal and borderline numbers for HDL cholesterol?

Normal: > 60
Borderline: 35-60

5

What class of lipid lowering drug is Atrovastatin?

HMG CoA reductase inhibitor (statin)

6

What are the 2 indications for Atrovastatin?

Dyslipidemia
CVD prevention

7

What is the MOA of Atrovastatin?

Inhibits HMG-CoA reductase
Increases hepatic LDL receptors, enhancing catabolism

8

What is HMG-CoA reductase responsible for?

An early, rate-limiting step in cholesterol biosynthesis

9

What are the 5 common adverse effects of Atrovastatin?

Nasopharyngitis
Myalgia
Skeletal myopathy
Impaired hepatic function associated with elevated serum transaminase levels
Jaundice

10

What are the 7 potential ocular side effects of Atrovastatin?

Diplopia
Elevated IOP
Ptosis
Pseudo-CME
Intraocular hemorrhage
Cataracts
Blurred vision

11

What is the 1 contraindicated drug for Atrovastatin?

Azoles

12

Which drugs interact with Atrovastatin to cause myopathy exacerbation?

Cyclospoirne
Erythromycin
Azoles

13

What class of lipid lowering drug is Fenofibrate?

Fibrate

14

What are the 3 indications for Fenofibrate?

Hypertriglyceridemia
Hypercholesterolemia
Combo with statins, or for statin intolerant patients

15

What is the MOA of Fenofibrate?

Stimulates nuclear receptor PPAR, which modulates transcription of insulin sensitive genes in liver, muscle, and adipose tissue
Enhances HDL production, inhibits triglyceride synthesis

16

What are the 3 common side effects of Fenofibrate?

Headache
Rhinits
Flu syndrome

17

What are the 7 serious side effects of Fenofibrate?

Hypersensitivity: SJS, TEN
Hepatic: Hepatitis, Cirrhosis
CV: Thromboembolism
Muscular: Myositis, myopathy, rhabdo

18

Which drugs interact with Fenofibrate to impair renal elimination?

Acyclovir
Aminoglycosides
Cyclosporin
Ganciclovir

19

Which drug interacts with Fenofibrate to cause impaired metabolism?

Sulfonylureas

20

What are the 3 indications for Niacin?

Hypertriglyceridemia
Hypercholesterolemia
Mixed dyslipidemia

21

What is the MOA of Niacin in dislypidemia?

Inhibits lipolysis in adipose tissue, resulting in reduced hepatic VLDL synthesis and production of LDLs in the plasma

22

Niacin is the most effective agent for increasing what?

HDL

23

What are the 9 common adverse effects of Niacin?

Headache
Pseudo CME
Flushing
Pruritus
Hyperpigmentation
Jaundice
Xeroderma
Toxic amblyopia
Orthostatic hypotension

24

What are the 2 serious adverse effects of Niacin?

Hepatotoxicity
Arrhythmias

25

What does niacin induce that causes flushing and/or Mueller cell toxicity?

Prostaglandin D2 production

26

What drugs interact with Niacin to cause an additive effect?

Alpha and Beta blockers

27

Cautions need to be taken when Rxing Niacin with what two conditions?

Diabetes - elevates sugar
Surgery - anti-platelet effects

28

What class of dyslipidemia drug is Ezetimibe?

Cholesterol Absorption Inhibitor

29

What is the MOA of ezetimibe?

Inhibits dietary and biliary cholesterol absorption as the small intestine brush border

30

What are the 3 common adverse effects to Ezetimbe?

Sinusitis
Flu
Diarrhea