Flashcards in Cancer Deck (6)
What are the indications for Methotrexate?
What is the MOA of methotrexate?
Folic acid analog that inhibits HGFR, and prevents FH4
Inhibits lymphocyte formation
Activates adensoine pathways
What is the serious adverse effect of Methotrexate?
What is the black box warning for Methotrexate?
Monitor bone marrow, liver, lungs, and kidneys for opportunistic infections
Potentially fatal myelosuppression with NSAIDs. Cipro, and penecillins
What drug combines with Methotrexate to cause elevated levels?