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Flashcards in Hormones Deck (29)
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1

What is the MOA of Levothyroxine Sodium?

Synthetic T-4

2

What are the ocular side effects of Levothyroxine Sodium?

Myasthenia Gravis-like (ptosis, diplopia, EOM paresis)

3

What are the CV and CNS adverse effects of Levothyroxine Sodium?

HTN
Pseudotumor cerebri
Hallucination

4

What are the indications for Estrone?

Menopause
Breast cancer
Prostate cancer
Osteoprosis prevention

5

What is the MOA of Estrone?

Binds to estrogen receptors, developing and maintaining female sex characteristics and repro systems

6

Which two hormone drugs have black box warnings?

Estrone
Yaz

7

Which two hormone drugs can cause CL intolerance?

Estrone
Yaz

8

What drug type can interact with Levothyroxine to cause an additive effect?

Sympathomimetics

9

What drug type can interact with Levothyroxine to cause an antagonistic effect?

Sympatholytics

10

What is the black box warning for Estrone?

Endometrial Cancer
Stroke
DVT
MI
Invasive breast cancer

11

What are the 6 common adverse effects of Estrone?

Headache/migraine
Elevated BP
Weight changes
Fluid retention
CL intolerance
Vision changes

12

What may occur when Estrone interacts with systemic steroids?

Increased adverse effects of steroid

13

When Estrone interacts with Omega-3's, what may occur?

Antagonized anti-hyperlipidemic effects

14

What are the 3 contraindications for Estrone?

Hypertension
Smoker
Migraine

15

What is the MOA for Yaz?

Suppresses LH and FSH, inhibiting ovulation

16

What are the severe adverse effects of Yaz?

MI
Stroke
Ocular Lesions

17

What is the black box for Yaz?

Smoking
CV events

18

What are the common adverse effects of Yaz?

Headache
Weight changes
Elevated BP
Increased cholesterol
CL intolerance

19

Yaz impairs the metabolism of what drug?

Cyclosporine

20

What happens when NSAIDs and Yaz interact?

Additive hyperkalemia

21

Yaz causes what when interacting with Tetracyclines, Penicillins, Cephalosporins, Macrolides, and Quinolones?

Decreased efficacy

22

What happens when Yaz and Ascorbic acid interact?

Decreased metabolism

23

What are the contraindications for Yaz?

HTN
Smoking
Migraine

24

What class of drug is Tamoxifen?

SERM

25

What is the MOA of Tamoxifen?

Binds to estrogen receptors, producing estrogenic and anti-estrogenic effects

26

What are the common adverse effects of Tamoxifen?

Dizziness
Headache
VA changes

27

What are the severe adverse effects of Tamoxifen?

Thromboembolism
Stroke
Pancytopenia
Retinopathy
Cataracts

28

Tamoxifen may increase the levels of which drugs?

Cyclosporine
Steroids
Oxycodone

29

Which drugs inhibit the hepatic production of the active metabolite of Tamoxifen?

Chlorpheniramine
Macrolides