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Flashcards in ED Deck (12)
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1

What are the 3 drug classes used for ED?

Phosphodiesterase inhibitors
Alpha-2 agonists
Prostaglandin-E1 analogs

2

What drug type is the first-line therapy for ED?

Phosphodiesterase inhibitors

3

What are the 2 indications for Sildenafil Citrate?

ED
Pulmonary Arterial hypertension

4

What is the action of Sildenafil Citrate?

Vasodilator

5

What is the MOA of Sildenafil Citrate?

PDE-5 inhibitor, which sustains the vasodilatory effects of nitric oxide-dependent synthesis of cGMP

6

What are the 4 common side effects of Sildenafil Citrate?

Headache
Abnormal vision
Dizziness
Nasal congestion

7

What are the 6 serious adverse effects of Sildenafil Citrate?

MI
Stroke
Ventricular tachycardia
Hypotension/shock
Anemia
Leukopenia

8

What are the 5 ocular side effects of Sildenafil Citrate?

Retinal hemorrhage
NAION
Vision loss
Elevated IOP
Cyanopsia

9

What may occur if Sildenafil Citrate interacts with Azoles, Erythromycins, or Cyclosporine?

Reduced metabolism

10

What may occur if Sildenafil Citrate interacts with alpha/beta blockers?

Additive effect

11

Sildenafil Citrate may interact with which 3 drugs and cause reduced Sildenafil metabolism?

Azoles
Erythromycins
Cyclosporine

12

Sildenafil Citrate may interact with which 2 drugs to cause an additive effect ?

Alpha-blockers
Beta-blockers