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Flashcards in Blood Thinners Deck (48)
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1

Arterial thrombosis usually consist of what type of clot?

Platelet-rich

2

Venous thrombosis is commonly triggered by what?

Blood stasis
Inappropriate activation of the coagulation cascade

3

What are the 2 types of anti-hemostatics?

Anticoagulants
Platelet inhibitors

4

Drugs that act within the extrinsic pathway affect what?

Synthesis of vitamin K dependent coagulation factors

5

What do drugs that act within the intrinsic pathway inhibit?

Activity of coagulation factors

6

What are the 2 anticogulent drug classes?

Vitamin K antagonists
Coagulation factor antagonists

7

What type of drug is Coumadin?

Vitamin K antagonist

8

What is the MOA of Coumadin?

Inhibits vitamin K dependent coagulation factor synthetis (II, VII, IX, X, proteins C and S)

9

What are the 9 common adverse effects of Coumadin?

Bleeding/bruising
Headache
Dizziness
Puritis
Edema
Dermatitis
Fever
Paresthesias
Alopecia

10

What are the 5 serious side effects of Coumadin?

Syncope
Vasculitis
Hemorrhage
Cholesterol embolism
Anemia

11

What is the antidote for Coumadin?

Vitamin K or prothrombin complex concentrate

12

What may occur if Coumadin interacts with Azoles, Macrolides, Fluoroquinolones, or Tetracyclines?

Impaired Coumadin metabolism

13

What may occur if Coumadin interacts wieh NSAIDs, Omega-3s/6s?

Additive blood thinning

14

Which 4 drug types can interact with Coumadin to impair metabolism?

Azoles
Macrolides
Fluoroquinolones
Tetracyclines

15

Which 2 drug types may interact with Coumadin to increase blood thinning effects?

NSAIDs
Omega3/6

16

What is the vitamin K antagonist?

Coumadin

17

What are the 3 indications for Enoxaparin?

Post-op DVT
Unstable angina

18

What is the delivery route for Enoxaparin?

IV

19

What are the two drugs that are delivered by IV?

Enoxaparin
Abciximab

20

What is the MOA of Enoxaparin?

Low MW heparin
Binds to circulating antithrombin and accelerates the irreversible inactivation of factor Xa

21

What are the 2 side effects of Enoxaparin?

Hemorrhage
Fever

22

What is the 1 serious side effect of Enoxaparin?

Anemia

23

What are the 2 antidotes for Enoxaparin?

Heparin
Protamine sulfate

24

What drug types interact with Enoxaparin to cause additional blood thinning?

NSAIDs or Omega 3/6s

25

When does caution need to be had with Enoxaparin?

Recent ocular surgery
Diabetic retinopathy
HTN
Diabetes

26

What kind of drug is Rivaroxaban?

Vitamin K inhibitor - blood thinner

27

What are the indications of Rivaroxaban?

DVT and stroke prophy

28

What is the MOA of Rivaroxaban?

Factor Xa inhibitor
Selectively blocks the active site of factor Xa, inhibiting blood coagulation

29

What are the 2 common side effects of Rivaroxaban?

Hemorrhage
Pruritis

30

What is the possible hypersensitivity to Rivaroxaban?

Steven's-Johnson syndrome