Flashcards in Blood Thinners Deck (48)
Arterial thrombosis usually consist of what type of clot?
Venous thrombosis is commonly triggered by what?
Inappropriate activation of the coagulation cascade
What are the 2 types of anti-hemostatics?
Drugs that act within the extrinsic pathway affect what?
Synthesis of vitamin K dependent coagulation factors
What do drugs that act within the intrinsic pathway inhibit?
Activity of coagulation factors
What are the 2 anticogulent drug classes?
Vitamin K antagonists
Coagulation factor antagonists
What type of drug is Coumadin?
Vitamin K antagonist
What is the MOA of Coumadin?
Inhibits vitamin K dependent coagulation factor synthetis (II, VII, IX, X, proteins C and S)
What are the 9 common adverse effects of Coumadin?
What are the 5 serious side effects of Coumadin?
What is the antidote for Coumadin?
Vitamin K or prothrombin complex concentrate
What may occur if Coumadin interacts with Azoles, Macrolides, Fluoroquinolones, or Tetracyclines?
Impaired Coumadin metabolism
What may occur if Coumadin interacts wieh NSAIDs, Omega-3s/6s?
Additive blood thinning
Which 4 drug types can interact with Coumadin to impair metabolism?
Which 2 drug types may interact with Coumadin to increase blood thinning effects?
What is the vitamin K antagonist?
What are the 3 indications for Enoxaparin?
What is the delivery route for Enoxaparin?
What are the two drugs that are delivered by IV?
What is the MOA of Enoxaparin?
Low MW heparin
Binds to circulating antithrombin and accelerates the irreversible inactivation of factor Xa
What are the 2 side effects of Enoxaparin?
What is the 1 serious side effect of Enoxaparin?
What are the 2 antidotes for Enoxaparin?
What drug types interact with Enoxaparin to cause additional blood thinning?
NSAIDs or Omega 3/6s
When does caution need to be had with Enoxaparin?
Recent ocular surgery
What kind of drug is Rivaroxaban?
Vitamin K inhibitor - blood thinner
What are the indications of Rivaroxaban?
DVT and stroke prophy
What is the MOA of Rivaroxaban?
Factor Xa inhibitor
Selectively blocks the active site of factor Xa, inhibiting blood coagulation
What are the 2 common side effects of Rivaroxaban?