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Flashcards in Diabetes Deck (55)
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1

What are the 5 types of oral Diabetes therapies?

Biguanides
Sulfonylureas
Thiazolidinedions/Glitazones
DPP-4 inhibitors
SGLT2 inhibitors

2

Which diabetic drug stimulates PPAR?

Pioglitazone

3

What are the 2 types of injectable diabetes drugs?

GLP-1 agonists
Insulin

4

What is the first line therapy for DM-II?

Metformin

5

What type of drug is Metformin?

Biguanide

6

Other than DM-II, what my Metformin be Rxed for?

Polycystic Ovary Syndrome

7

What does Metformin activate to suppresses gluconeogensis?

AMP activated protein kinase (AMPK)

8

When AMPK is suppressed, what 3 things happen?

Suppression of hepatic gluconeogenesis
Suppression of intestinal glucose absorption
Increase in insulin sensitivity

9

What are the 3 common effects of Metformin?

Headache
Metallic taste
Rash

10

What are the 2 serious adverse effects of Metformin?

Lactic acidosis
Megaloblastic anemia

11

What happens when fish oils or decongestants interact with Metformin?

Increase in blood sugar

12

Metformin may interact with what 2 things to cause an increase in blood sugar?

Fish oils
Decongestants

13

Metformin may interact with what to decrease blood sugar?

Flaxseed

14

When Metformin interacts with flaxseed, what happens?

Decreased blood sugar

15

When ___ interacts with Metformin, hypoglycemia gets masked.

Beta Blockers

16

What may occur when Metformin interacts with Beta-blockers?

Masks hypoglycemia

17

What may occur when Metformin interacts with Aminoglycosides, Amphotericin, Ganciclovir, or Acyclovir?

Nephrotoxicity-induced lactic acidosis

18

Metformin may interact with what 4 drugs/types to cause nephrotoxicity-induced lactic acidosis?

Aminoglycosides (micins)
Amphotericin
Ganciclovir
Aciclovir

19

What may occur when Metformin interacts with Cyclosporin?

Decreased metabolism

20

The interaction of Metformin with what drug class may cause a decrease in metabolism?

Cyclosporine

21

What does a hepatic activation of Beta-2 cause?

Glycogenolysis
Gluconeogenesis

22

What does a pancreatic activation of Beta-2 cause?

Increased insulin release

23

What does a pancreatic activation of alpha-2 cause?

Decreased insulin release

24

Which Diabetes drug is a Sulfanylurea?

Glipizide

25

What is the MOA of Glipizide?

Stimulates pancreatic islet beta cells
Binds ATP-dependent K+channel blocker, causing depolarization, Ca++ release and vesicle effusion

26

What does stimulation of pancreatic islet beta cells cause?

Insulin release

27

What are the 3 common side effects of Glipizide?

Headache
Hypoglycemia
Photosensitivity

28

What is the 1 serious adverse effect of Glipizide?

Death

29

Which is the diabetes drug that may cause death?

Glipizide

30

What may occur when Glipizide interacts with steroids or decongestants?

Antagonistic