Flashcards in Diabetes Deck (55)
What are the 5 types of oral Diabetes therapies?
Which diabetic drug stimulates PPAR?
What are the 2 types of injectable diabetes drugs?
What is the first line therapy for DM-II?
What type of drug is Metformin?
Other than DM-II, what my Metformin be Rxed for?
Polycystic Ovary Syndrome
What does Metformin activate to suppresses gluconeogensis?
AMP activated protein kinase (AMPK)
When AMPK is suppressed, what 3 things happen?
Suppression of hepatic gluconeogenesis
Suppression of intestinal glucose absorption
Increase in insulin sensitivity
What are the 3 common effects of Metformin?
What are the 2 serious adverse effects of Metformin?
What happens when fish oils or decongestants interact with Metformin?
Increase in blood sugar
Metformin may interact with what 2 things to cause an increase in blood sugar?
Metformin may interact with what to decrease blood sugar?
When Metformin interacts with flaxseed, what happens?
Decreased blood sugar
When ___ interacts with Metformin, hypoglycemia gets masked.
What may occur when Metformin interacts with Beta-blockers?
What may occur when Metformin interacts with Aminoglycosides, Amphotericin, Ganciclovir, or Acyclovir?
Nephrotoxicity-induced lactic acidosis
Metformin may interact with what 4 drugs/types to cause nephrotoxicity-induced lactic acidosis?
What may occur when Metformin interacts with Cyclosporin?
The interaction of Metformin with what drug class may cause a decrease in metabolism?
What does a hepatic activation of Beta-2 cause?
What does a pancreatic activation of Beta-2 cause?
Increased insulin release
What does a pancreatic activation of alpha-2 cause?
Decreased insulin release
Which Diabetes drug is a Sulfanylurea?
What is the MOA of Glipizide?
Stimulates pancreatic islet beta cells
Binds ATP-dependent K+channel blocker, causing depolarization, Ca++ release and vesicle effusion
What does stimulation of pancreatic islet beta cells cause?
What are the 3 common side effects of Glipizide?
What is the 1 serious adverse effect of Glipizide?
Which is the diabetes drug that may cause death?