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Flashcards in GI Deck (11)
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1

What is the MOA of Esomeprazole?

Proton pump inhibitor that inhibits gastric parietal cell H+/K+ATPase, inhibiting gastric acid secretion

2

What are the serious adverse effects of Esomeprazole?

SJS
TEN

3

What are the common adverse effects of Esomeprazole?

HA
Constipation or diarrhea
Xerostomia
Flatulence

4

What are the indications for Esomeprazole?

GERD
Gastric Ulcer prophy
Hypersecretory disorders
H. pylori infection

5

Esomeprazole can impair the absorption of what?

Azoles
Certain antivirals

6

What may occur when Esomeprazole and CAIs interact?

Exacerbation of Hypomagnesemia

7

What are the indications for Cimetidine?

GERD
Peptic Ulcer
Dyspepsia

8

What is the MOA of Cimetidine?

H2 blocker that selectively antagonizes parietal cell H2 receptors

9

What are the common adverse effects of Cimetidine?

Headache
Dizziness

10

What are the serious adverse effects of Cimetidine?

Food and drug allergies
Blood dyscrasias
Psychosis
Depression
Reversible impotence
Gynecomastia

11

What substances does Cimetidine impair?

Caffeine
Cyclosporine