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Flashcards in anti-virals Deck (120)
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31

moa of preotease inhibitors

assumble of virions requires HIV-1 protease (pol gene) to cleave polypeptide of HIV mRNA into functional parts. so prevents maturation of new viruses

32

what makes ritonavir special?

inhibits P450 to boost other drug concentrations

33

common side effects of all protease inhibitors

hyperglycemia
lipodystrophy
nausea and diarrhoea

34

side effects of indinavir pelase

nephropathy
hematuria

35

proteas inhibitor that can cause nephropathy and hematuria please

indinavir

36

a/se: hyperglycemia, gi upset, lipodystrophy

protease inhibitors, the NAVIRs

37

what drug si contraindicated with protease inhibtitors and why

rifampin
CYP inducer so would decreased protease inhibitor concentration

38

please list the NRTIs

abacavir
didanosine
emtricitabine
lamicudine
stacudine
tenofocir
zidocudine (formerly azt)

39

how do NRTis work?

completely inhibit nucleotide binding to reverse transcriptase and terminate the DNA chian because they lack a 3'OH,

40

what NRTI is not a nucleoside

tenovofir - doesn't need to be phosphorylated to be active

41

what is the NRTI for use in pregos?

zidovudine/formerly known as azt

42

what is the NRTI used for general prophylaxis

zidovudine

43

a/se of all NRTIs pelase

bone marrow suppression
peripheral neurpahty

44

a/se unique to the NRTI nucleosides

lactic acidosis

45

what NRTI casues anaemia?

zidovudine

46

what NRTI causes pancreatitits

didanosine

47

how can you prevent some of the side effects of NRTIs

bone marrow suppression = give EPO and G-CSF

48

a/se of bone marrow suppression, peripheral neuropathy

NRTIs

49

a/se of lactic acidosis

metformin ;)
nucleoside NRTI (all but tenovofir)

50

a/se of pancreatitis

didanosine

51

a/se of anaemia

ziduvodine

52

please list the NNRTis

delavirdine
efavirenz
nevirapine

53

MOA of the NNRTIs please

bind to reverse transcriptase at site different from NRTIs
do nto require phosphyrlation to be active or to compete with nucletides

54

list the drugs that DO not require to be Pi in HIV treatment

tenovofir, an NRTI
all the NNRTIs (delavirdine, efacirnez, nevirapine)

55

what drugs for HIV are contraindicated in pregos

NNRTIs: delavirdine, efavirnez

56

what are the ase of the NNRTis

rash and hepatotoxicity (indinavir, a protease inhibitor cause hematuria and nephrotoxicity)

57

a/se of efavirenz

vivid dreams and CNS symptoms

58

a/se rash and hepatotoxicity

NNRTIsL delavirdine, efavirenz, nevirapine

59

a/se of vivid dreams and CNS symptoms

efavirenz

60

list the integrase inhibitors

raltegravir