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Flashcards in Antidepressants: MAOIs Deck (18):
1

What does MAOI stand for?

Monoamine oxidase inhibitors

2

Out of TCA, SSRI, and MAOI, what is the most hazardous class of drugs?

MAOI

3

What is the greatest concern for why MAOIs are hazardous?

They can cause a hypertensive crisis

4

How is a MAOI hypertensive crisis triggered by?

Eating foods rich in tyramine

5

What is the mechanism of action of MAOIs?

Prevent the destruction of ALL monamines, causing levels to rise

6

What monamines do MAOIs effect?

ALL OF THEM: serotonin, dopamine, norepinephrine

7

What are some examples of MAOIs?

Isocarboxazied
Phenelzine
Tranylcypromine
Selegiline

8

Out of TCAs, SSRIs, and MAOIs, which is the best at relieving depression?

They are all equal in relieving depression

9

Since TCAs, SSRIs, and MAOIs are all equal in relieving depression, why are MAOIs one of the last choices and who usually gets prescribed MAOI drugs?

They are second or third choice antidepressants for most patients because they are so hazardous. The ones who are prescribed MAOIs are those who have not responded already to a SSRIs, TCAs, and other safer drugs

10

Is there any instance in which MAOIs are the first choice of anti-depressants? If so, for who?

Yes; those with atypical depression

11

Do MAOIs cause CNS stimulation or sedation?

Stimulation

12

MAOIs effects usually produce what effect: hypotension or hypertension

Usually hypotension since MAOIs reduce blood pressure, but they can be the cause of severe hypertension if they eat foods that are rich in tyramine

13

Can you prescribe a patient both an MAOI and SSRI?

No; increased risk for serotonin syndrome

14

Can you prescribe a patient both a TCA and MAOI?

No; produces hypertensive episodes or hypertensive crisis

15

Can you prescribe a patient both a MAOI and meperidine (demerol)

No; can cause hyperpyrexia (excessive elevation in temp)

16

Can you prescribe a patient both a MAOI and an OTC cold medicine?

No; can produce a hypertensive crisis

17

What kind of administration methods are available for MAOIs?

Mostly oral; but there is a transdermal MAOI (selegiline), which by the way is the ONLY transdermal antidepressant treatment for major depression

18

If giving the transdermal MAOI, is there still the same risk for hypertensive crisis when eating foods with tyramine?

No; the risk is much lower in the MAOI transdermal treatment