T3-Allergy Medications: Antihistamines-MJ Flashcards Preview

Pharm I > T3-Allergy Medications: Antihistamines-MJ > Flashcards

Flashcards in T3-Allergy Medications: Antihistamines-MJ Deck (22):
1

What are 5 histamine effects?

Runny nose, sneezing
Watery, itchy eyes
Rash, itching
Vasodilation (decreased BP)
Bronchospasm

2

What are the two main groups of allergy meds?

First and second generation

3

Are first generation lipid soluble?

Yes

4

What are 2 characteristics of first generations?

Greater anticholinergic effect
Easily penetrate the BBB

5

What are three common first generations?

Diphenhydramine
Promethazine
Hydroxyzine

6

Which of the first generation can be given IV?

Diphenhydramine

Works fast, 100% absorption if given IV; given for anaphalytic shock

7

What firs generation is NOT SAFE for children under the age of 2? Why?

Promethazine; can cause very high respiratory depression

Good for motion sickness, NV though..just not in kids under age 2

8

What are the 4 common second generations?

Cetirizine
Loratidine
Desloratidine
Fexofenadine

9

Do second generations cross BBB well?

No

10

Second generations have very little ____ effects and have a much longer ____

little sedation
much longer half-life

11

With second generations, do they have high or low side-effects?

Do they have anti-cholinergic effects?

Low side-effects

Don't have anti-cholinergic effects

12

Of the second generations, which drug has some sedation?

Cetirizine

13

Of the second generations, which two drugs are basically the same? What is the difference?

Loratidine and desoratidine
Desoratidine is a prescription drug and therefore more expensive. They both produce the same effect

14

How often do we have to give a first generation?

q 4-6

15

How often do we give a second generation?

q day

16

First or second generation: certirizine

Second

*has some sedative effects unlike other second generations

17

First or second generation: promethazine

First

*good for N/V, motion sickness; not good for kids under 2 though (respiration depression)!!!!

18

First or second generation: diphenhydramine

first

19

First or second generation: fexofenadine

second

20

First or second generation: loratidine

second

21

First or second generation: hydroxyzine

first

*good for sleep and itching relief

22

First or second generation: desloratidine

second

*more expensive than loratidine even though they are the same drug