T3-Analgesics: Muscle Relaxers-MJ Flashcards Preview

Pharm I > T3-Analgesics: Muscle Relaxers-MJ > Flashcards

Flashcards in T3-Analgesics: Muscle Relaxers-MJ Deck (26):
1

What are the two topics here?

Muscle relaxants
Drugs for spasticity

2

What are muscle spasms?

Involuntary contractions

3

What do muscle spasms result from?

Musculoskeletal injuries

4

Are muscle spasms painful?

Yes

5

What type of patients often have muscle spasms?

Femur fracture patients

6

Do muscle relaxers work on the muscle?

No, they work on brain and CNS

7

What neurotransmitter do muscle relaxers work on?

GABA

8

So if muscle relaxers work on GABA, what are some precautions patients need to be aware of?

-It can cause sedation
-Avoid ETOH
-Be cautious with driving
-There is abuse potential

9

What are 3 muscle relaxers?

Carisoprodol
Cyclobenzaprine
Diazepam

10

Cyclobenzaprine (muscle relaxer) is very similar to what class of drugs?

TCA

11

So if clyclobenzaprine is similar to TCAs, what effects can be seen when someone is taking clyclobenzaprine?

Sedation
Anticholinergic effects (can't see, can't pee, can't shit, can't spit)

12

If clyclobenzaprine is combined with another serotinic drug, is that okay?

NO! It can cause serotonin syndrome

13

What is spasticity?

Heightened muscle tone

14

What is spasticity caused by?

MS (musculosclerosis)
CP (cerebral palsy)
Stroke

15

What are the ONLY 3 drugs for muscle spasticity?

Baclofen
Diazepam
Dantrolene

16

Dantrolene: the only drug that is not centrally acting. So what does that mean?

It will work DIRECTLY on the muscle

17

Dantrolene may help with the spasm, but what does it decrease?

Muscle strength

18

What should flash in our head when we hear we have to give dantrolene to our patient?

LIVER TOXICITY

19

Who is most at risk for liver toxicity if we have to give them dantrolene?

WOMEN who are >35 have a high risk for liver toxicity

20

Dantrolene is also a treatment for ______.

Malignant hyperthermia

21

Is malignant hyperthermia common or rare?

Rare

22

Is malignant hyperthermia life threatening?

Yes!

23

How is malignant hyperthermia triggered?

General anesthesia

24

If a patient has to get general anesthesia, what is done?

They may be screened; family history is the major risk factor for if this could happen to the patient

25

What does malignant hyperthermia cause?

Extreme rigidity and temperature

26

If a patient has malignant hyperthermia, what drug do we want to have handy? Why?

Dantrolene-because it is the treatment for malignant hyperthermia!