Flashcards in T3-Analgesics: Headaches-MJ Deck (44)
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1
What is the most common headache?
Tension
2
What headache is the disabling headache and needs aggressive treatment?
Migraine
3
Migraines cause _____ head pain
Throbbing
4
What percent of migraines are unilateral?
60%
5
What percent of migraines are bilateral?
40%
6
Do migraines cause N/V?
Yes
7
Migraines cause a person to be sensitive to ___ and ___
Light and sound
8
What is the average length of a migraine?
24 hours
9
So why do people get migraines when that is in the brain and the brain doesn't have pain receptors (you can poke, cut through the brain and no pain)?
Vessels and arteries IN THE BRAIN DO have pain receptors
10
Do migranes cause vasoconstriction or vasodialiaton?
Vasodialaton
11
Do migraines cause inflammation?
Yes
12
What nerve is effected from migraines?
Trigeminal
13
What promotes migraines?
CGRP
14
What surpasses migraines?
Serotonin
15
If we activate ______ receptors, that will depress the migraines.
Serotonin 1B,1D receptors
16
Which migraine medication stops a migraine AFTER it has started?
Abortive
17
What are the 2 migraine specific drugs?
Serotonin 1B,1D agonists (triptans)
Ergot alkaloids
18
What are triptans selective to?
Serotonin 1B,1D
19
What nerve does triptans work on?
Trigeminal nerve complex
20
The triptans induce _______.
Cerebral vasoconstriction
21
What do triptans block?
CGRP
22
What are 3 examples of triptans?
Sumatriptan
Eletriptan
Rizatriptan
23
What are the side effects of triptans (3)?
Vasoconstriction of coronary arteries
Heavy arms and chest pressure
Serotonin syndrome
24
We want triptans to induce _____ vasoconstriction, but the side effects sometimes cause vasoconstriction of ______.
We want them to induce CEREBRAL vasoconstriction but a side effect of triptans is causing vasoconstriction of CORONARY ARTERIES
25
Should you take a triptan if you have coronary artery disease or have had a MI? Why or why not?
NO! Side effect of triptan is vasoconstriction of coronary arteries !--NOT GOOD
26
Is the triptan side effect of heavy arms and chest pressure something to be concerned with?
No, UNLESS there are risk factors for the patient having heart problems
27
Triptans can also cause serotonin syndrome. Is this common or rare?
RARE unless taking some other drug that increases serotonin levels
28
What are the 4 big symptoms of serotonin syndrome?
Altered mental status
Fever, sweating
Hyperreflexia
Clonus
29
What are three drug classes that would cause too much serotonin when taking with a triptan?
MAOI
SSRI
SNRI
30
