Autonomic Regulation of the Heart - Quiz 1 Flashcards

1
Q

role of SA node on actions on the heart

A
  • changes nodal action potential

- changes heart rate

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2
Q

parasympathetic role on heart rate

A
  • decreases heart rate
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3
Q

sympathetic role on heart rate

A
  • increases heart rate
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4
Q

sympathetic role on contractility

A
  • increases contractility
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5
Q

sympathetic role on vasculature

A
  • constricts smooth muscle of blood vessels
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6
Q

autonomic role of baroreceptor reflex

A
  • regulates autonomic response to changes in pressure and volume in the vasculature
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7
Q

NE or EPI binds to

A
  • beta1 adrenergic receptors on SA nodal cells
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8
Q

beta receptors on SA nodal cells have what kind of receptor

A
  • G protein coupled receptor
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9
Q

NE or EPI binding to B1 adrenergic receptor causes what?

A
  • increases open state probability of HCN (mostly Na+) - due to cAMP
  • increases opening of T type Ca channels - due to more negative membrane potential
  • increases opening of L-type Ca channels - due to cAMP -> PKA which opens DHP
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10
Q

opening of HCN and T-type Ca channels causes

A
  • faster rate of phase 4 depolarization

- major effect

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11
Q

opening of L-type Ca channels causes

A
  • less positive threshold
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12
Q

additional sympathetic effect of NE or EPI binding to B1 adrenergic receptor

A
  • increased conduction velocity of action potentials

- increased heart rate

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13
Q

increased conduction velocity of action potentials is what kind of effect

A
  • positive dromotropic
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14
Q

increased heart rate is what kind of effect

A
  • positive chronotropic
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15
Q

parasympathetic effect Ach binds to

A
  • muscarinic receptors
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16
Q

what type of receptor are muscarinic receptors

A
  • G coupled protein receptors
17
Q

results of Ach binding to muscarinic receptor

A
  • increases permeability to K+
18
Q

result of increased permeability to K+

A
  • hyper polarization maximum diastolic polarization more negative
  • slows depolarization
19
Q

additional parasympathetic effect of Ach binding to muscarinic receptor

A
  • decreased conduction velocity

- decreased heart rate

20
Q

decreased conduction velocity is what kind of effect

A
  • negative dromotropic
21
Q

decreased heart rate is what kind of effect

A
  • negative chronotropic
22
Q

sympathetic stimulation effects on cardiac muscle contractility

A
  • increased tension developed
  • increased rate of tension increase
  • increased rate of relaxation
23
Q

sympathetic stimulation effects on cardiac muscle contractility a result of

A
  • L-type channels increasing permeability to Ca2+
  • increasing activity of Ca2+ pumps to make myocyte ready for next depolarization and increase amount of Ca2+ in stores for next release burst
24
Q

where are the baroreceptor sensory receptors located?

A
  • aortic arch

- carotid sinus

25
Q

integrators in maintenance of blood pressure/volume

A
  • brainstem and hypothalamus determine response
26
Q

afferent pathway travels by

A
  • cranial nerves
27
Q

efferent pathway travels by

A
  • ANS pre- and post-ganglionic neurons
28
Q

effects of maintenance of blood pressure/volume are

A
  • ANS outflow to targets

- blood vessels, SA node, ventricles, endocrine tissues

29
Q

what do baroreceptors due in response to increases or decreases in mechanical stretch

A
  • alter firing
30
Q

what organ center receives the synapses from the baroreceptors and other nuclei

A
  • brainstem cardiovascular control center
31
Q

hemorrhage pathway

A
  • decrease arterial pressure
  • decrease firing by arterial baroreceptors
  • decrease parasympathetic discharge to heart
  • increase sympathetic discharge to heart
  • increase heart rate
32
Q

parasympathetic efferent pathway travels via

to where

result

A
  • vagus nerve
  • SA node of heart
  • decrease heart rate
33
Q

sympathetic efferent pathway travels via

A
  • sympathetic chain ganglia
34
Q

sympathetic efferent pathway travels to where

A
  • SA/AV node
  • adrenal medulla
  • blood vessels
35
Q

sympathetic efferent pathway result

A
  • increase heart rate
  • secrete Epi/NE
  • constrict blood vessels using NE