Bacteria 2 Flashcards Preview

Pathology > Bacteria 2 > Flashcards

Flashcards in Bacteria 2 Deck (80)
Loading flashcards...
31

What does invasive disease lead to?

Bacteremia

32

What is found on bacterial capsule that causes Sepsis or DIC?

LPS or PspC

33

Why do encapsulted bacteria and meningitis go to CSF?

No complement for opsonization

34

In sepsis what does LPS stimulate?

Toll Like Receptors to induce systemic cytokine secretion and endothelial cell activation

35

What is DIC?

Systemic coagulation caused by bacteria

36

What limits Gonococci's ability to cause DIC?

They have LOS instead of LPS

37

Most common caused of community acquired pneumonia ?

Strep pneumoniae

38

What special attachment does Strep pneumoniae have on its polysaccharide capsule?

PspC

39

What virulence factor of Strep Pneumoniae inhibits alternate complement pathway?

PspA

40

Who is the pneumococcal conjugate vaccine for?

Children younger than 5 and adults with risk factors

41

Who is the pneumococcal polysaccharide vaccine for?

Children two years or older

42

What is one of the main nutritional requirements for Neisseria?

Iron

43

Where is Neiserria found?

Not normal flora, exogenous

44

Incubation time N. meningitides?

Less than a week

45

What is N. meningitidis susceptible to?

Penicillin

46

What causes the petechial rash in N. meningitidis?

Microhemorrhages in capillaries

47

What is Waterhouse Friderichsen syndrome?

Hemorrhage into adrenals

48

Are vaccinations effective for meningococcal disease?

Yes, doesn't cover group B though which is biggest in neonates

49

Why do N. meningitidis vaccines not work in neonates?

Neonates cannot respond to capsular antigen vaccine

50

How does N. Gonorrhea differ from N. Meningitidis?

Different capsule allows different behavior

51

Where does N. Gonorrhea attach?

Columnar and transitional epithelia mucous membranes of genital tract, rectum, and nasopharynx

52

N. Gonorrhea IgA protease allows for what?

Evasion of mucosal immunity

53

Why has it been difficult to make a vaccine for N. Gonorrhea?

Antigenic variability

54

What is a defining characteristic of H. influenza?

Unencapsulated mostly

55

What can make H. influenza dangerous?

Encapsulation and endotoxin

56

What is the window of vulnerability for invasive disease of Type B?

3 months to 3 years due to bad protective antibody response to type B capsular antigens

57

What is a good way to vaccinate toddlers and infants with Type B?

Conjugate capsule with protein

58

What causes Diphtheria?

Corynebacterium diphtheria

59

What causes the membrane formation of Diphtheria?

Local epithelial necrosis which releases exotoxin A

60

What is characteristic of Whooping Cough?

Lymphocytosis