Flashcards in Bacteria 2 Deck (80)
What does invasive disease lead to?
What is found on bacterial capsule that causes Sepsis or DIC?
LPS or PspC
Why do encapsulted bacteria and meningitis go to CSF?
No complement for opsonization
In sepsis what does LPS stimulate?
Toll Like Receptors to induce systemic cytokine secretion and endothelial cell activation
What is DIC?
Systemic coagulation caused by bacteria
What limits Gonococci's ability to cause DIC?
They have LOS instead of LPS
Most common caused of community acquired pneumonia ?
What special attachment does Strep pneumoniae have on its polysaccharide capsule?
What virulence factor of Strep Pneumoniae inhibits alternate complement pathway?
Who is the pneumococcal conjugate vaccine for?
Children younger than 5 and adults with risk factors
Who is the pneumococcal polysaccharide vaccine for?
Children two years or older
What is one of the main nutritional requirements for Neisseria?
Where is Neiserria found?
Not normal flora, exogenous
Incubation time N. meningitides?
Less than a week
What is N. meningitidis susceptible to?
What causes the petechial rash in N. meningitidis?
Microhemorrhages in capillaries
What is Waterhouse Friderichsen syndrome?
Hemorrhage into adrenals
Are vaccinations effective for meningococcal disease?
Yes, doesn't cover group B though which is biggest in neonates
Why do N. meningitidis vaccines not work in neonates?
Neonates cannot respond to capsular antigen vaccine
How does N. Gonorrhea differ from N. Meningitidis?
Different capsule allows different behavior
Where does N. Gonorrhea attach?
Columnar and transitional epithelia mucous membranes of genital tract, rectum, and nasopharynx
N. Gonorrhea IgA protease allows for what?
Evasion of mucosal immunity
Why has it been difficult to make a vaccine for N. Gonorrhea?
What is a defining characteristic of H. influenza?
What can make H. influenza dangerous?
Encapsulation and endotoxin
What is the window of vulnerability for invasive disease of Type B?
3 months to 3 years due to bad protective antibody response to type B capsular antigens
What is a good way to vaccinate toddlers and infants with Type B?
Conjugate capsule with protein
What causes Diphtheria?
What causes the membrane formation of Diphtheria?
Local epithelial necrosis which releases exotoxin A