Bio 252 -Peripheral Vascular Disease Flashcards Preview

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Flashcards in Bio 252 -Peripheral Vascular Disease Deck (18):
1

Peripheral vascular disease not in main arteries mostly in _______

periphery (arms & legs)
-may also be in veins or lymphatics

2

PVD largely involves ___ ONLY

arteries

3

PVD has changes similar to coronary arteries this means ________ deterioration over ______

gradual deterioration over decades

4

Claudication

-pain as a result of ischemia

5

embolus

non-normal component of blood (ex. air bubble, fat, clot) moving in blood

6

thrombus

stationary blood clot

7

2 forms of peripheral vascular disease

1) Acute Arterial Occlusion

2) Atherosclerotic Occlusive Disease

8

Acute Arterial Occlusion

-acute interruption to perfusion d/t thrombus or embolus (blood clot)

9

Mnfts of Acute Arterial Occlusion

7 "ps"
-pistol shot (pain that occurs)
-pallor (pale colour) no blood perfusion to vessel
-pain (ischemic pain)
-pulselessness ex. absence of pedal pulse
-parathesia -odd feeling, tingling or numbing, abnormal sensation
-paralysis-ischemia can cause loss of fx
-polar (cold) -blood carries heat, distribute heat through blood, not receiving adequate blood flow, experience cold

10

Diagnosing Acute Arterial Occlusion

-Physical exam
-blood flow assessment
-Doppler ultrasound -helps to assess blood flow to vessels

11

Treatment of Acute Arterial Occlusion

-surgery
-thrombolytics (category of drug) --drug breaks down the clot, dissolves the clot
-anticoagulants (category of drug) --prevents future clots

12

Atherosclerotic occlusive disease

-in lower extremities (usually happens in legs)
-atherosclerosis takes long to develop (gradual development, takes years), But occlusion happens quite rapidly
-blood/lymph is not being carried away from tissue adequately causing an increase in waste & fluid accumulation which then causes ischemia and tissue damage

13

Atherosclerotic occlusive disease happens more frequently to

-Elderly (mnfts in 50,60,70, because degeneration of tissue change affects blood vessels)
In younger people with diabetes melliuts (complication of diabetes is vascular disease)

14

Compensation for atherosclerotic occlusive disease

-Vasodilation
-Anaerobic metabolism
-Collateralization (angiogenisis, formation of new vessels to tissue, around obstructed vessels had to happen before occlusion long term scenario, cannot form vessels in minutes)

15

Possible complications of anaerobic metabolism

Metabolic acidosis: lactic acid is a by product of anaerobic metabolism, build up of lactic acid causes metabolic acidosis because lactic acid is a fixed acid not a volatile

16

manifestations of Atherosclerotic occlusive disease

-intermittent claudication -- ischemic pain upon walking
-others develop later

17

Treatment of atherosclerotic occlusive disease

-symptomatic management
-decrease cardiovascular risks

18

what happens if there is not treatment of atherosclerotic occlusive disease

if no treatment ulceration and gangrene happens resulting in amputation