Guillain-Barre syndrome

Question 1

what is Gullian barre syndrome

Answer 1

• autoimmune & inflammation damage to peripheral nervous system
• aute, generalized paralysis

Question 2

what always comes with autoimmunity

Answer 2

autoimmunity causes inflm, so with autoimmunity comes inflm

Question 3

how does classic autoimminty come about

Answer 3

-for classic autoimmunity always preceded by an infection that triggers autoimmunity, so immune response is producing antibodies and T cells, then something changes in immunity causing target of self component

Question 4

gullian barre syndrome essentially presents as

Answer 4

acute generalized paralysis

Question 5

Etiology of Guillian Barre syndrome

Answer 5

• idiopathic

- preceded by infection (1-4 wks)

Question 6

guillian barre syndrome preceded by

Answer 6

infect (1-4 wks before)
most common: campylobacter jejuni (bacterium, tend to encounter in unpasteurized milk, poultry, contaminated water)
also can be causes by viruses such as EBV

Question 7

Patho of Guilian-Barre syndrome

Answer 7

antibodies and t cells target myelin sheath (in peripheral nervous system)
schwann cell damage

Question 8

what cells make up the myelin sheath in the peripheral nervous system

Answer 8

schwann cells

Question 9

mnfts of Guillian-Barre syndrome

Answer 9

• progressive ascending muscle weakness & paralysis
• partheisias (numbness & tingling sensation in periphery)
• partheisia (ascending usually origin in periphery hands & feet)
• deep muscle pain (shoulder & thigh)
• complete paralysis (may or may not happen based on intervention)
• respiratory failure (aprox 25%) approximately 25% will progress till respiratory failure

Question 10

Diagnosing Guillian-Barre syndrome

Answer 10

• history (history to exclude things such as myasthenia gravis)
• physical exam (weakness & reflexes)
• nerve conduction (stimulate nerve electrically & see if conducting, if demylinated conduction will be impaired)
• CSF (for exclusion, some changes elevated protien content because inflm in PNS if close to spinal cord)

Question 11

Treatment of Guillan-Barre syndrome

Answer 11

• life support (respiratory system)
• plasmapheresis (take blood seperate palasma from cells, plasma has antiboides and other neurotoxic compounds discard plasma, to get rid of antiboides from circulation)
• IV igG (give antibodies because low from plasmapheresis)
• 80-90% recover in 6-12 months(

Question 12

with Guillan-Barre syndrome disease mnfts _________ and recover in ________

Answer 12

mnfts in ascending (periphery damage first & vital organs-breathing muscles last)
and recover in descending (vital organs, breathing recover first then periphery)

Question 13

Guillian-barre syndrome you have to ________ not _______

Answer 13

you have to intervene not self-limiting