Lymphoma Flashcards Preview

Bio 252- atherosclerosis > Lymphoma > Flashcards

Flashcards in Lymphoma Deck (20):
1

Lymphomas are

malignancies (cancers) that arise in lymphoid tissues (tissues satiated with leukocytes)
ex of tissues - lymph nodes, spleen, thymus & tonsils

2

Hodgkins Lymphoma

group of cancers characterized by Reed-Sternberg cells. These cells begin malignancy in a single lymph node. Than spread to continuous lymph nodes.

3

Non-Hodgkins Lymphoma

Heterogeneous lymphatic cancers, meaning that it may spread to various tissues (including bone marrow) where it may disperse in numerous directions.

4

Manifestations of both Lymphomas relate to

uncontrolled lymph node & lymphoid tissue growth, bone marrow involvement.

5

Symptoms of both lymphomas include

fever, fatigue & weight loss which relate to rapid growth of abnormal lymphoid cells & tissue

6

which lymphoma has the Reed-Sternberg cells

Hodgkins Lymphoma

7

Hodgkins lymphoma etiology

largely idiopathic (unkown), proposed causes exposure to carcinogens & viruses as well as genetic

8

Risks for Hodgkins Lymphoma:

-people w history of infectious mononucleosis
-if some blood related (in immediate family) has history of HL
-receiving long term immunosuppresive therapy
-working w some wood products
-exposure to herbicide agent orange

9

Patho of Hodgkins lymphoma:

-unicentric (single center of origin)
-Initiates in single lymph node, typically above diaphragm
-spreads by contiguous extension (sequence extension) along lymphatic system
-Malignant cell of HL is Reed-sternberg cell

10

what is the essential diagnostic criteria for Hodgkins lymphoma

Reed-Sternberg cells

11

Manifestations of hodgkins Lymphoma

-painless enlargement of a single node or group of nodes, initial node usually above diaphragm
-decline in cellular immunity, more susceptible to viral infections (herpes zoster, fungal, protozoal)
-localized symptoms from compression of organs affected by tumor growth. Ex. cough & fluids in pleural cavity d/t tumor growth near lungs.
-B symptoms: systemic fever, chills, night sweats and weight loss of 10% or more

12

Medical management of Hodgkins lymphoma

early stage (1&2) short course of chemotherapy, followed by radiation (general tx), for some only radiation
advanced stage (3&4& all B stages) combination chemotherpay with doxorubicin, bleomycin, vinblastine and darcrabazine

13

general goal of Hodgkins lymphoma treatment is to _______ patient because

cure patient because survival rate is 80%

14

treatment of Hodgkins lymphoma is determined by

stage of the disease

15

Etiology of Non-Hodgkins lymphoma

primarily idiopathic

16

Risks for Non-Hodgkins lymphoma

-people with immunodeficiencies & autoimmune disorders
-undergoing tx to cancer, have/had organ transplants, have viral infection such as epstein-barr virus or HIV
-exposure to pesticides, solvents &dyes (ex. Agent orange)
-age increase predisposition, as each progressive decade of life has increased causes of NHL

17

patho for Non-hodgkins lymphoma

-can originate in any lymphoid tissue, most commonly in lymph nodes
-from there can spread throughout body into other tissues ex. liver, spleen, & bone marrow
-type of NHL determines path, ex. B cell lymphomas reproducing in B cell areas, T cell lymphomas multiplying in T cell areas
-patho & classification can also be determined by cell type affected, level of maturation & anatomic sites

18

Mnfts of Non-Hodgkins Lymphoma

-swollen or enlarged lymph nodes
-less aggressive forms swollen lymph nodes can come and go
-symptoms may be nearly absent till later stages
-later stages bone marrow commonly involved
-decline in humoural immunity (T cells & B cells)
-Lymphomatous masses may compromise organ functioning
-B symptoms: persistent fever, drenching night sweats, and unintentional weight loss greater than 10%

19

what is the most common mnfts of Non-Hodgkins Lymphoma

swollen or enlarged lymph nodes

20

Medical management of Non-Hodgkins Lymphoma

-depends on type
-if form is mild & localized radiation alone may combat disease
-aggressive forms tend to require combination chemotherapeutic agents & radiation
-low grade lymphomas approved to utilize interferon(antivirals that disrupt replication)