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Flashcards in Bleeding Disorders Deck (44)
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30

acquired fibrinolytic defects

cancer
liver disease
DIC
local relase plasminogen activators from prostate surgery

31

lab results of fibrinolytic diseases

prolonged PTT and PT
increased d-dimers

32

treatment of fibrinolytic disorders

supportive with plasma infusions
antifibrinolytic drugs (if NO DIC)

33

antifibrinolytic drugs

epsilon aminocaproic acid
tranexamic acid

34

DIC labs

prolonged PT, aPTT
elevated d-dimers
decreased fibrinogen, platlet count, rbcs, antithrombin, protein c, protein S
presence of schistocytes

35

treatment DIC

plasma to replace coagulation factors and anticoagulants
cryoprecipitate (to replace fibrinogen)
platelets, RBC

**heparin will stop DIC, but may lead to bleeding

36

liver disease parameters

bleeding due to decreased synthesis of coagulation factors, fibronlytic factor inhibitors

clotting due to decreased clearance of activated coagulation factors

37

liver disease labs

prolonged PTT and PT, but this doesnt correspond with bleeding
low factor levels except VIII

38

treatment of liver disease

transplant; everything else is only temporary

39

vitamin K is required for

gamma-carboxylation of coagulation factors which improves coagulation factor binding to phospholipid surface of platelet

40

ways to get vitamin K def

dietary-poor intake, malabsorption due to pancreatic or small-bowel disease, alcoholism
medications
warfarin!

41

lab studies vitamin k def

prolonged PT, PTT
factor 2, 7, 9, 10 decreased
normal 5 (so we know it's not liver disease)

42

treatment vitamin k def

give vitamin K
fresh frozen plasma can get you out of a quick bind, but not long lasting

43

must give vitamin K concurrently because

short half life of factor VII in plasma