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Flashcards in Breast cancer Deck (17):
1

risk factors

personal history of breast cancer
genetic mutation BRAC1 BRAC2
FH of breast/ovarian cancer
prior breast irradiation at young age
childbearing absent or after 30
early periods/late menopause
hot
high BMI
high alcohol intake

2

fibrocystic changes
associated with what

benign
lumpiness
thickening
swelling

women period

3

fibroadenomas
who

solid round rubbery lump that moves under the skin when touched - mouse

young women

4

infections

red, warm, tender, lumpy

5

micro calcifications

tiny deposits of calcium - majority are harmless
small % may be cancerous

6

screening

mam
50-70s
every 3 years

7

what does triple assessment include

clinical exam
imaging
fine needle aspiration/biopsy core

8

what happens when cancer is confirmed

CT for staging/MRI

9

radiotherapy following breast conservation surgery - just breast alone

negative sentinel biopsy
noted conning micro metastases 0.2-2mm in SNB
or < 4nodes in an adequate axillary node clearance

10

radio following breast conservation - boost to tumour bed for women

under 54 on the day of surgery
posterior margin <1mm for invasive disease after full thickness incision

11

radio following mastectomy - chest wall radio

tumour >5cm
4 or more nodes involved
involved resection margins
T4 disease

12

radio to ipsilateral axilla

>1 positive macro metastases sentinel node
extensive ECS post axillary clearance

13

radio to the supraclavicular fossa

4 or more nodes involved

14

adjuvant treatment

tamoxifen - 10 years
letrozole - 5 years

15

who is trastuzumab given to

whose cancer cells express HER2-neu as measured by IHC or FISH

16

what should be considered for locally advanced cancer and for who

radio as initial therapy for

a primary tumour that is considered inoperable

for patients still inoperable following primary systemic therapy

consider post surgery for all px

17

how should px with T>4b tumours be treated

with 0.5cm bolus following mastectomy to increase the skin dose