Cell Cycle Flashcards
interphase
G1= vigorous cell growth and metabolism
G0= cells that permanently cease dividing
S= DNA rep occurs
G2= prep for division
Mitosis
diploid
consists of prophase, metaphase, anaphase, telophase, cytokinesis
prophase
chromosomes become visible
centrosomes separate and migrate towards opp poles
chromatids join at centromere
mitotic spindles and asters form
nuclear envelope disappears
metaphase
centromeres of chromosomes align at equator
anaphase
centromeres of chromosomes split simultaneously
pulled towards poles via motor proteins of kinetochores
telophase
chromatin forms
new nuclear membrane forms
nucleoli reappear
spindle disappears
cytokinesis
begins in late anaphase
cleavage furrow forms
two identical daughter cells form
meiosis
haploid
cell division producing gametes
occurs only in sex cells
DNA rep
DNA helices separate to form rep forks at each end (unzips DNA)
each strand acts as a template for complementary strand
DNA polymerase starts to add nucleotides
copy of DNA is made via semi conservative rep
semi conservative rep
each DNA is composed of 1 old and 1 new strand
transcription (replication->DNA-RNA)
transfers DNA gene base sequence to complementary base sequence of mRNA
loosens histones from DNA in area to be transcribed
binds to promoter region
mediates the binding of RNA polymerase
translation (protein synthesis)
converts base sequences of nucleic acids into AA sequence of proteins
each 3-base sequence on DNA represented by codon
tRNA binds specific AA at one stem; anticodon at other end binds mRNA codon at ribosomes via H bonds; ribosome coordinates coupling of mRNA and tRNA
codon
complementary 3-base sequence on mRNA
main categories of cancer
sarcoma
carcinoma
sarcoma
malignant tumor of mesenchymal origin
carcinoma
malignant tumor of epithelial origin
proto-oncogenes
normal dividing cells
turn into cancer cells when tumor suppressor genes are inactive and cells divide continuously (can be due to a mutation in gene)
carcinogen
cancer causing agent
multistep theory
loss of tumor suppressor genes and over expression of oncogenes will cause cancer
chemotherapy
drugs used to shrink or kill cancer cells
radiation therapy
radiation in the form of x-rays of protons used to kills cancer cells
cell differentiation
switch off certain unneeded cells and switch on needed ones
causes development of specific and distinctive features in cells
3 sites of mRNA and tRNA coupling
aminoacyl
peptidyl
exit
stratified cuboidal
salivary
mammary
sweat
secretion, protection, excretion