Cellular Accumulations Flashcards Preview

Pathology -- Gen Path > Cellular Accumulations > Flashcards

Flashcards in Cellular Accumulations Deck (24):
1

What is lipofucin?

Undigested remnants of lipid peroxidation, occurs with cellular aging

2

Causes of hypertrophy of the smooth endoplasmic reticulum?

Adaptive response to drugs
Esp. barbituates, alcohol, and insectisides

3

Give examples of two diseases in which cytoskeletal abnormalities build up

Mallory bodies in alcoholic liver disease
Neurofibrillary tangles in Alzheimer

4

Where does fatty change tend to happen?

Liver
Can also hit heart, muscle, and kidney

5

What happens in fatty change?

Lipid transport via complex with lipid acceptor proteins doesn't work. Ribosomal dispersion or damage from free rads or Ca causes decreased protein synthesis. Can't make the lipid acceptor proteins, so you can't get them out.

6

Causes of fatty change?

Chronic alcohol intake, carbon tetrachloride, acetaminophen

7

Clear vacuoles may contain...

Water, glycogen, fat, etc.

8

Two types of calcification

Dystrophic
Metastatic

9

Dystrophic calcification happens when...

Ca is deposited into necrotic tissue

10

Metastatic calcification happens when..

Ca is deposited into viable tissue (hypercalcemia)

11

When might metastatic calcification occur?

Hyperparathyroidism, Vit D toxicosis, tumors with increased bone catabolism (myeloma), or renal failure (secondary para)

12

What does calcification look like under a microscope?

Granular, basophilic material

13

Eosinophilic cytoplasmic desposits lead to...

Hyaline change

14

What are Russell bodies?

Accumulation of immunoglobulins in endoplasmic reticulum of plasma cells

15

Hyaline change in the proximal renal tubules means...

you're leaking protein into the urine

16

Important details for Glycogen accumulation?

Assocaited with abnormal glucose values, glycogen metabolism or glycogen storage diseases

17

Two examples of exogenous pigments that can accumulate in cells

1. Anthracosis (carbon particles in the macrophages of the lungs)
2. Tattoo Ink (dermal macrophages)

18

Example of an endogenous pigment that builds over time

Lipofuscin -- Wear and tear, aging pigment
Made from membrane turnover
Prominent in heart and liver

19

What should you think of if you see lipofuscin in a younger patient

Severe malnutrition
Cachexia assocaited with cancer

20

What does lipofuscin look like

Golden brown, granular
Perinuclear in cytoplasm

21

What is hemosiderin?

A break down product of hemoglobin by macrophages made of aggregates of ferritin granules

22

What is hemochromatosis?

A genetic disease resulting in the extreme accumulation of hemosiderin. Hits the liver, pancreas, skin, and pituitary

23

What is bilirubin made of?

The non-iron component of hemoglobin, normally removed in the bile

24

Stain used for lipid

Oil Red O