Flashcards in Tumor Growth and Metastasis Deck (23):
Two examples of factors that promote angiogenesis?
VEGF and basic-FGF
Features of angiogenic vessels brought to tumors
Tortuous, Irregularly shaped
Poor Blood Flow
How do cells lose cohesiveness with their clonal populations?
Loss of homotypic adhesion proteins, Downregulation of E-cadherin.
How do tumor cells manage to migrate through the ECM?
Attachment to matrix components
Degradation of ECM
How do tumor cells attach to matrix components
Increased ECM adhesion proteins (integrins+IgFamily)
Increased Laminin+Fibronectin binding
Loss of BM Orientation
How do tumor cells degrade ECM?
Secretion of serine, cysteine, and MMPs
MMP __ and __ clear type 4 collagen
2 and 9
Bronchiogenic carcinoma tends to head to...
the adrenal medulla
Gastric cancer tends to head to...
Two tumors with known strong anti-tumor immune responses
Renal Cell Carcinoma
Immunomodulators considered for treatment of cancer
Three paraneoplastic syndromes associated with overproduction of proteins
Waldestrom's macroglobulinemia (IgM)
Medullary Carcinoma of the Thyroid
What is produced in Multiple Myeloma
light chains (Bence Jones proteins) that cause renal damage
What is produced in Waldestrom's macroglobulinemia
IgM that causes hyperviscosity syndrome
What is produced in Medullary carcinoma of the thyroid
Calcitonin leading to amyloidosis
Examples of three kinds of cancer that cause overproduction of hormones
1. Testicular/Ovarian -- Feminnizing/Masculinizing Hormones
2. Insulinoma -- hypoglycemia
3. Adrenal cortical carcinoma (causes cushings)
ACTH ssproduociated with the development of which kind of cancer?
Symptoms associated with Cachexia?
anorexia, malabsorption, generalized wasting, fever
Cancer associated with hypercalcemia from parathyroid-like hormone release?
Squamous Cell Carcinoma of the Lung
Cancer associated with hypercoagulability syndromes?
Pancreatic Cancer (migrating thrombophlebitis)
Four famous tumor markers
Whats the point of staging a tumor?
Assessing the degree of invasion and metastasis.