Neoplasia I Flashcards Preview

Pathology -- Gen Path > Neoplasia I > Flashcards

Flashcards in Neoplasia I Deck (25):
1

Characteristics of dysplasia

Pathologic alteration of cell size, shape, and organization
Loss of cellular uniformity, architecture
May be reversible

2

What is carcinoma in situ?

Marked dysplastic change involving the entire thickness of the epithelium
"Pre-invasive malignant"

3

Neoplasms are typically composed of two things. What are they?

Parenchyma (proliferating neoplastic cells) and stroma (supporting tissue).

4

What determines the biological behavior of a tumor?

Parenchymal cell type

5

What is neoplasm stroma comprised of?

Connective tissue, BV, Lymphatics

6

Two types of parenchymal cells

Mesenchymal and Epithelial

7

Two examples of cancers not from a single parenchymal cell type. How many germ cell layers do they come from?

Mixed Cell Neoplasms (1)
Teratoma (multiple)

8

How to name a benign mesenchymal tumor?

Cell of Origin + oma
ex. fibroma, osteoma, rhabdomyoma

9

How to name a benign epithelial tumor?

Cell of origin + adenoma
ex. mammary gland adenoma, ovarian cystadenoma

10

What are papillomas?

Neoplasms tht form microscopic papilla (ex. squamous papilloma)

11

What are polyps?

Neoplasms which project above a mucosal surface into a lumen

12

How to name a malignant mesenchymal tumor?

Cell of Origin + Sarcoma
ex. fibrosarcoma, osteosarcoma, rhabdomyosarcoma

13

How to name a malignant epithelial tumor derived from or forming glandular patterns?

Cell of Origin + Adenosarcoma
ex. mammary adenosarcoma, ovarian cystadenocarcinoma

14

How to name a malignant epithelial tumor that isn't glandular?

Cell of Origin + Carcinoma
ex. Squamous cell carcinoma, basal cell carcinoma

15

Five neoplasm exceptions to the neoplasm naming rules

1. Melanoma - Carcinoma of Melanocytes
2. Seminoma - Carcinoma of Spermatogenic epithelium
3. Lymphompa - Malignant lymphoid neoplasms
4. Multiple Myeloma -- Neoplasm of plasma cells
5. Leukemia -- Neoplasms of stem cell in the bone marrow

16

Differentiation refers to...

Extent to which parenchymal cell of a neoplasm resemble comparable normal cells in morphology and function

17

What is anaplasia

lack of differentiation

18

True or false. Lack of differentiation if the consequence of dedifferentiation.

False

19

Characteristics of anaplastic cells

Pleomorphism, Basophilic cytoplasm
Nuclei -- hyperchromatic, clumping of chromatin
Increased Nuc:Cytoplasm Ratio
Bizarre mitotic figures

20

Best criteria for distinguishing malignant from benign neoplasms

Metastasis

21

Two types of malignant cancers that cannot metastasize

Glial Cell tumors (gliomas)
Basal cell carcinomas

22

Most common route for carcinoma dissemination?

Lymphatics

23

Most common route for sarcoma dissemination?

Hematogenous

24

Most common sites of 2ndary metastasis?

Lung and Liver

25

Seeding of body cavities/surfaces is characteristic of...

Ovarian carcinoma