Hemostasis and Coagulation Flashcards Preview

Pathology -- Gen Path > Hemostasis and Coagulation > Flashcards

Flashcards in Hemostasis and Coagulation Deck (21):
1

Mediators responsible for inhibition of platelet aggregation?

PGI2
NO
ADPase

2

Molecules that bind and inhibit thrombin

Heparin-like molecules (which accelerate anti-thrombin III inactivating thrombin)

3

Activity of thrombomodulin?

Activated Protein C, which leads to lysis of Factors 5 and 8

4

What does alpha 2 macroglobulin do?

Binds thrombin for removal from the circulation

5

Antithrombotic properties of resting endothelial cells (6)

1. Inhib. platelet aggregation
2. Binds+Inhibits thrombin
3. Thrombomodulin
4. Synth. protein S: cofactor for protein C
5. alpha2 macroglobulin
6. Fibrinolysis

6

Three prothrombotic properties of activated endothelium

1. Endothelial cell injury leads to platelet aggregation/adhesion
2. Activation of coagulation cascade
3. Inhibition of fibrinolysis

7

How do activated ECs activate the coagulation cascade?

Tissue factor synthesis induced by cytokines or bacteria, which activates Factor 7

8

Three important actions of platelets upon activation

1. Adhesion/Shape Change
2. Secretion
3. Aggregation

9

Platelet adhesion to the subendothelium requires _____ and _____ receptor

von Willebrand's factor
GpIb receptors

10

What do platelets secrete?

Alpha Granules and Dense Bodies

11

What binding is important for platelets' role in primary plug formation

GpIIb-IIIa and fibrinogen

12

Contents of Platelet alpha granules

fibrinogen, fibronectin, V, VIII, PF-4, PDGF, TGF-b

13

Contents of electron dense bodies

ADP, ATP, Ca, histamine, serotonin, epinephrine

14

Most important mediators of platelet aggregation

ADP
TxA2, thrombin

15

Intrinsic pathway is activated by ______ in vitro

Hageman Factor

16

Antithrombins inhibit...

Thrombin
AND
9a, 10a, 11a, 12a

17

Protein C and S inactivate...

5 and 8

18

Two types of plasminogen activators

Urokinase-like plasminogen activators
tissue-type plasminogen activators

19

When are urokinase-like plasminogen activators used

In fluid phase (serum/tissue)

20

When are tissue type plasminogen activators used?

Made by endothelium, activated when bound to fibrin

21

Decreased vW factor will also cause a lower level of....

8