Principles of Healing and Regeneration Flashcards Preview

Pathology -- Gen Path > Principles of Healing and Regeneration > Flashcards

Flashcards in Principles of Healing and Regeneration Deck (21):
1

______ are the main component of granulation tissue

Fibroblasts.
The provide the collagen that makes a provisional environment for parenchymal cell proliferation.

2

____ is a key factor in fibroblast proliferation and fibrosis

TGF-b.
It mediated chronic fibrosis in many disease states.

3

How do fibroblasts organize/collagen strengthenq

Contraction of myoepithelial cells

4

Wound strength is at ___% after the first week and ____% by the 3rd month.

10%
70-80%

5

Last component of tissue regeneration

reinnervation

6

Granulation tissue is characterized by..

Loose, edamatous stroma with proliferating fibroblasts and multiple tiny arteries. Principle multiplying cells are fibroblasts and endothelial cells (angiogenesis).

7

What occurs in healing by first intention?

Wound edges are pulled together to minimize tissue defect. Intact basement is aligned for easy epithelization. Minimal damage to architecture.

8

What occurs in healing by second intention?

Large tissue defect due to ulcer, abscess, or extensive necrosis.
Wound contraction must occur on maturation of the granulation tissue. Contracture of the scar.

9

Most common factor inhibiting resolution of the healing process?

Infection

10

Collagens associated with the wound healing process

I and II

11

Cross linking of collagen requires...

Calcium and Vitamin C

12

Which adhesion molecules are Ca dependent? Which ones are not?

Dependent -- Selectins + Cadherins
Indep -- Integrins + Ig super family

13

What do cadherins do?

Mediate homotypic adherence between like cells and are tissue specific

14

Two important stimulators of angiogenesis?

FGF, VEGF

15

_____ help cleave the ECM during angiogenesis

MMPs

16

Early granulation tissue is marked by...

1. Edema
2. BVs
3. Loose Collagen

17

In healing by first intention, how long to restore epithelial layer?
How long till neutrophils infiltrate the area?

1-3 days
2-5 days

18

How long till active rpoliferation of fibroblasts, angiogenesis?

2-7 days

19

How long till maturation of granulation tissue?

2-3 weeks

20

What do you call a healing response with too much granulation tissue

proudn flesh

21

What do you call a healing response with excessive collagen

Keloid