Leukocyte Extravasation and Phagocytosis Flashcards Preview

Pathology -- Gen Path > Leukocyte Extravasation and Phagocytosis > Flashcards

Flashcards in Leukocyte Extravasation and Phagocytosis Deck (17):
1

Early activation promotes redistribution of P-selectin from...

Weibel-Palade Bodies (minutes)

2

L-selectin. Who expresses it? What is its role?

Leukocytes.
Binding to endothelial cells and homing lympho. to LNs

3

E-selectin. Who expresses it? What is its role?

Endothelial Cells.
Binds Lewis carbohydrates

4

P-selectin. Who expresses it? What is its role?

Endothelial Cells and platelets.
Early activation of EC by re-distribution of P-selectin from Weibel-Palade bodies.

5

What do integrins bind to?

he RDG sites of fibronectin and vitronectin

6

Integrins are composed of....

alpha and beta chains
Different cobinations for families of integrin molecules

7

beta1 integrins (VLA) are important because...

They mediate the attachment of lymphocytes to the endothelium

8

beta2 integrins (LFA-a family) are important because...

They mediate the binding of leukocytes to endothelium and function in phagocytosis and antigen presentation

9

PECAM is expressed on activated....

leukocytes

10

ICAM and VCAM are ecpressed on ECs activated by...

IL1, TNF

11

ICAM binds to....

high affinity LFA4 on neutrophils

12

VCAM binds to...

VLA integrins on monocytes and lymphocytes

13

What is LAD1

A leukocyte deficience in which there is a defect in beta1 integrins

14

What is LAD2?

Lack of sialyl Lewis X glycoproteins (the ligand for selectins)

15

Killing and degradation is accomplished most by...

oxygen dependent processes
(i.e. production of reactive oxygen intermediates, myloperoxidase)

16

What does myeloperoxidase do?

Converts H2O2 to hypochlorite
Most efficient bactericidal system in PMNs

17

What happens in Chediak-Higashi syndrome?

defective degranulation and delayed microbial killing