Chapter 16 lecture 2 Flashcards
What does cicatrix means?
-Scar
What is another term for mucous membrane pemphigoid?
-Cicatrical pemphigoid
T/F Mucous membrane pemphigoid is twice as common as pemphigus
True
If you see an intraoral blood blister what should you be thinking about?
-mucous membrane pemphigoid
What is the most significant complication in mucous membrane pemphigoid?
-Ocular involvement
If mucous membrane pemphigoid progresses what happens to the conjunctiva?
- Inflamed
- Eroded
What are adhesions from mucous membrane pemphigoid from the conjunctiva becoming inflamed and eroded which leads to scarring?
Symblepharons
If scarring in mucous membrane pemphigoid occurs and turn the eyelids inward what is that called?
-Entropion
T/F The cornea can produce keratin as a protective mechanism in pemphigoid
True
What type of split do you see in pemphigoid?
-Subepithelial split
What do you see in a direct immunofluorescence in pemphigoid?
- C3
- IgG (both along basement membrane)
What is Erythema Multiforme?
-Blistering ulcerative mucocutaneous condition of uncertain etiopathogenesis
What infections can cause erythema multiforme?
- Herpes simplex (1)
- Mycoplasma pneumoniae
What medications can cause Erythema multiforme?
- Antibiotics
- Analgesics
What is Erythema mulftiforme (EM) major aka?
-Steven’s Johnson syndrome
What three things do you see on the spectrum of EM?
- EM minor
- EM major
- Txoic epidermal necrolysis
What is toxic epidermal necrolysis aka?
-Lyell’s disease
What are the prodromal symptoms of EM?
- Fever
- Headache
- Cough
- Sore throat
How long does EM last for?
2-6 weeks with 20% having recurrent episodes
What do early lesions of EM look like?
- Flat
- Round
- Red
A highly characteristic skin lesion with EM are called what and what are they?
- Target lesions
- Concentric circular erythematous rings resembling a target or bull’s eye
T/F With EM pts may become dehydrated due to an inability to ingest liquids
True
To make the diagnosis of Steven-Johnson syndrome what must there be involved?
- Skin
- Oral mucosa
- Ocular or genital involvement
What is the most sever form of EM?
Toxic epidermal necrolysis
