Chapter 17: Nutrient-Drug Interaction Flashcards by isabelle _

Q

substance other than food intended for use in diagnosis, cure, mitigation, treatment, and prevention

A

drug

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Q

the result of the action between a drug and a nutrient that would not happen with the nutrient or drug alone

A

drug-nutrient interaction

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Q

a broad term that includes drug-nutrient interactions and the effect of a medication on nutritional status

A

food-drug interaction

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Q

the study of the interactions between drugs and their receptors and the series of events that result in a pharmacologic response

A

pharmacodynamics

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Q

a science that deals with the progressive movement and the alteration of chemical substances within the body

it is the study of the mathematical relationship among the absorption, distribution, metabolism, and excretion of individual medicines over time

A

pharmacokinetics

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Q

originally interpreted as physician-induced malnutrition

A

iatrogenic malnutrition

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Q

mechanisms of drug-nutrient interactions - alteration of food intake

medication that alters appetite

A

amphetamines

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Q

mechanisms of drug-nutrient interactions - alteration of food intake

medication that interferes with taste

A

amphetamines

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Q

mechanisms of drug-nutrient interactions - alteration of food intake

medication that causes nausea and vomiting

A

digitalis

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Q

mechanisms of drug-nutrient interactions - alteration of food intake

medication that changes salivary secretion/dry mouth

A

phenobarbital

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Q

mechanisms of drug-nutrient interactions - alteration of food intake

medication that causes sores/inflammation in the mouth

A

methotrexate

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Q

mechanisms of drug-nutrient interactions - alteration of nutrient absorption (luminal effect)

change in acid secretion

A

antacids

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Q

mechanisms of drug-nutrient interactions - alteration of nutrient absorption (luminal effect)

motility

A

laxatices

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Q

mechanisms of drug-nutrient interactions - alteration of nutrient absorption (luminal effect)

binding actions to nutrient

A

antacid binds P

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Q

mechanisms of drug-nutrient interactions - alteration of nutrient absorption (mucosal effect)

damage to intestinal mucosa caused by intensive therapies

A

-

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Q

mechanisms of drug-nutrient interactions - alteration of nutrient metabolism and utilization

structural analogues

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A

warfarin to vitamin K

Q

mechanisms of drug-nutrient interactions - alteration of nutrient metabolism and utilization

competitive inhibition

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A

phenobarbital and folate

Q

mechanisms of drug-nutrient interactions - alteration of nutrient metabolism and utilization

altered enzyme activity and pharmacologically active agents

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A

Monoamine oxidase inhibitors (MAOI) and tyramine

Q

mechanisms of drug-nutrient interactions - alteration of nutrient excretion

increased excretion

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A

diuretics

Q

mechanisms of drug-nutrient interactions - alteration of nutrient excretion

displacement of nutrients

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A

aspirin and folate

Q

effect of nutrient on drug actions

alteration of absorption of orally administered drugs (3)

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A

-by changing stomach acidity
-stimulating digestive enzymes
-competing for absorptive sites

Q

effect of nutrient on drug actions

alteration of drug distribution

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A

-

Q

effect of nutrient on drug actions

alteration of drugs’ metabolism and excretion by altering urine pH

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A

-

Q

effect of nutrient on drug actions

food exerting antagonistic pharmacologic action

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A

-

effect of nutrient on drug actions when taken with food, drugs absorption may slow down or completely not absorbed

-

relating to a lumen (= the inside space of a tube-shaped organ in the body)

luminal

effect of nutrient on drug actions food taken with drugs produce less side effects

-

timing of oral medication with food intake drugs taken on an _____ stomach

empty

timing of oral medication with food intake drugs taken _____ hr before meal

timing of oral medication with food intake 1/2

timing of oral medication with food intake drugs taken with _____

meals

timing of oral medication with food intake drugs taken _____ mins after meal

30-35 mins

timing of oral medication with food intake drugs taken in a full glass of _____ (with or w/o meals)

water