classic presentations 3 Flashcards Preview

2016 Rapid Review! > classic presentations 3 > Flashcards

Flashcards in classic presentations 3 Deck (46):
1

Painless jaundice

Cancer of the pancreatic head obstructing bile duct

2

Palpable purpura on buttocks/legs, joint pain, abdominal pain, hematuria

Henoch-Schönlein purpura (IgA vasculitis affecting skin and (child) kidneys)

3

Pancreatic, pituitary, parathyroid tumors

MEN 1 (autosomal dominant)

4

Periorbital and/or peripheral edema, proteinuria (> 3.5g/day), hypoalbuminemia, hypercholesterolemia

Nephrotic syndrome

5

Pink complexion, dyspnea, hyperventilation

Emphysema (“pink puffer,” centriacinar [smoking] or panacinar [α1-antitrypsin deficiency])

6

Polyuria, renal tubular acidosis type II, growth failure, electrolyte imbalances, hypophosphatemic rickets

Fanconi syndrome (multiple combined dysfunction of the proximal convoluted tubule)

7

Pruritic, purple, polygonal planar papules and plaques (6 P’s)

Lichen planus

8

Ptosis, miosis, anhidrosis

Horner syndrome (sympathetic chain lesion)

9

Pupil accommodates but doesn’t react

Neurosyphilis (Argyll Robertson pupil)

10

Rapidly progressive limb weakness that ascends following GI/ upper respiratory infection

Guillain-Barré syndrome (acute inflammatory demyelinating polyradiculopathy subtype)

11

Rash on palms and soles

Coxsackie A, 2° syphilis, Rocky Mountain spotted fever

12

Recurrent cold (noninflamed) abscesses, unusual eczema, high serum IgE

Hyper-IgE syndrome (Job syndrome: neutrophil chemotaxis abnormality)

13

Red “currant jelly” sputum in alcoholic or diabetic patients

Klebsiella pneumoniae pneumonia

14

Red “currant jelly” stools

Acute mesenteric ischemia (adults), intussusception (children)

15

Red, itchy, swollen rash of nipple/areola

Paget disease of the breast (sign of underlying neoplasm)

16

Red urine in the morning, fragile RBCs

Paroxysmal nocturnal hemoglobinuria

17

Renal cell carcinoma (bilateral), hemangioblastomas, angiomatosis, pheochromocytoma

von Hippel-Lindau disease (dominant tumor suppressor gene mutation)

18

Resting tremor, rigidity, akinesia, postural instability,

Parkinson disease (loss of dopaminergic neurons in substantia shuffling gait nigra pars compacta)

19

Retinal hemorrhages with pale centers

Roth spots (bacterial endocarditis)

20

Severe jaundice in neonate

Crigler-Najjar syndrome (congenital unconjugated hyperbilirubinemia)

21

Severe RLQ pain with palpation of LLQ

Rovsing sign (acute appendicitis)

22

Severe RLQ pain with deep tenderness

McBurney sign (acute appendicitis)

23

Short stature, café au lait spots, thumb/radial defects, ^incidence of tumors/leukemia, aplastic anemia

Fanconi anemia (genetic loss of DNA crosslink repair; often progresses to AML)

24

Single palmar crease

Down syndrome

25

Situs inversus, chronic sinusitis, bronchiectasis, infertility

Kartagener syndrome (dynein arm defect affecting cilia)

26

Skin hyperpigmentation, hypotension, fatigue

1° adrenocortical insufficiency (eg, Addison disease) causes ^ACTH and ^α-MSH production)

27

Slow, progressive muscle weakness in boys

Becker muscular dystrophy (X-linked missense mutation in dystrophin; less severe than Duchenne)

28

Small, irregular red spots on buccal/lingual mucosa with blue-white centers

Koplik spots (measles [rubeola] virus)

29

Smooth, moist, painless, wart-like white lesions on genitals

Condylomata lata (2° syphilis)

30

Splinter hemorrhages in fingernails

Bacterial endocarditis

31

"Strawberry tongue”

Scarlet fever, Kawasaki disease

32

Streak ovaries, congenital heart disease, horseshoe kidney, cystic hygroma at birth, short stature, webbed neck, lymphedema

Turner syndrome (45,XO)

33

Sudden swollen/painful big toe joint, tophi

Gout/podagra (hyperuricemia)

34

Swollen gums, mucosal bleeding, poor wound healing, petechiae

Scurvy (vitamin C deficiency: can’t hydroxylate proline/lysine for collagen synthesis)

35

Swollen, hard, painful finger joints

Osteoarthritis (osteophytes on PIP [Bouchard nodes], DIP [Heberden nodes])

36

Systolic ejection murmur (crescendo-decrescendo)

Aortic stenosis

37

Telangiectasias, recurrent epistaxis, skin discoloration, arteriovenous malformations, GI bleeding, hematuria

Osler-Weber-Rendu syndrome

38

Thyroid and parathyroid tumors, pheochromocytoma

MEN 2A (autosomal dominant RET mutation)

39

Thyroid tumors, pheochromocytoma, ganglioneuromatosis

MEN 2B (autosomal dominant RET mutation)

40

Toe extension/fanning upon plantar scrape

Babinski sign (UMN lesion)

41

Unilateral facial drooping involving forehead

LMN facial nerve (CN VII) palsy; UMN lesions spare the forehead

42

Urethritis, conjunctivitis, arthritis in a male

Reactive arthritis associated with HLA-B27

43

Vascular birthmark (port-wine stain) of the face

Nevus flammeus (benign, but associated with Sturge-Weber syndrome)

44

Vomiting blood following gastroesophageal lacerations

Mallory-Weiss syndrome (alcoholic and bulimic patients)

45

Weight loss, diarrhea, arthritis, fever, adenopathy

Whipple disease (Tropheryma whipplei)

46

“Worst headache of my life”

Subarachnoid hemorrhage