oncogenes/tumor suppressor genes Flashcards Preview

2016 Rapid Review! > oncogenes/tumor suppressor genes > Flashcards

Flashcards in oncogenes/tumor suppressor genes Deck (27):
1

ALK

Oncogene
gene product: Receptor tyrosine kinase
associated neoplasm: Lung adenocarcinoma

2

BCR-ABL

Oncogene
Tyrosine kinase
CML, ALL

3

BCL-2

Oncogene
Antiapoptotic molecule (inhibits apoptosis)
Follicular and diffuse large B cell lymphomas

4

BRAF

Oncogene
Serine/threonine kinase
Melanoma, non-Hodgkin lymphoma

5

c-KIT

Oncogene
Cytokine receptor
Gastrointestinal stromal tumor (GIST)

6

c-MYC

Oncogene
Transcription factor
Burkitt lymphoma

7

HER2/neu (c-erbB2)

Oncogene
Tyrosine kinase
Breast and gastric carcinomas

8

JAK2

Oncogene
Tyrosine kinase
Chronic myeloproliferative disorders

9

KRAS

Oncogene
GTPase
Colon cancer, lung cancer, pancreatic cancer

10

MYCL1

Oncogene
Transcription factor
Lung tumor
L=Lung

11

MYCN

Oncogene
Transcription factor
Neuroblastoma
N=Neuroblastoma

12

RET

Oncogene
Tyrosine kinase
MEN 2A and 2B, medullary thyroid cancer

13

APC

Tumor suppressor gene
Colorectal cancer (assoc. w. FAP)

14

BRCA1/BRCA2

Tumor suppressor gene
associated condition: Breast and ovarian cancer
gene product: DNA repair protein

15

CDKN2A

Tumor suppressor gene
Melanoma, pancreatic cancer
p16, blocks G1-->S phase

16

DCC

Tumor suppressor gene
Colon cancer
DCC- Deleted in Colon Cancer

17

DPC4/SMAD4

Tumor suppressor gene
Pancreatic cancer
DPC—Deleted in Pancreatic Cancer

18

MEN1

Tumor suppressor gene
MEN 1
Menin

19

NF1

Tumor suppressor gene
NeuroFibromatosis type 1
Ras GTPase activating protein (neurofibromin)

20

NF2

Tumor suppressor gene
NeuroFibromatosis type 2
Merlin (schwannomin) protein

21

PTEN

Tumor suppressor gene
Breast cancer, prostate cancer, endometrial cancer

22

Rb

Tumor suppressor gene
Retinoblastoma, osteosarcoma
Inhibits E2F; blocks G1-->S phase

23

TP53

Tumor suppressor gene
Most human cancers, Li-Fraumeni syndrome
p53, activates p21, blocks G1-->S phase

24

TSC1

Tumor suppressor gene
Tuberous sclerosis
Hamatin protein

25

TSC2

Tumor suppressor gene
Tuberous sclerosis
Tuberin protein

26

VHL

Tumor suppressor gene
von Hippel-Lindau disease, renal cell carcinoma
Inhibits hypoxia inducible factor 1a

27

WT1/WT2

Tumor suppressor gene
Wilms Tumor (nephroblastoma)