Flashcards in Common presentation of hematological malignancies Deck (34):
What are the microcytic anemias?
Anemia of chronic disease
What does ferritin measure?
Body Fe stores
What does TIBC measure?
Number of open spots on transferritin
What does retic count measure? What is normal?
Reticulocyte count (immature RBCs)
What does urea breath test check for?
What are the three common causes of Fe deficiency anemia?
What is the treatment for a gastric ulcer?
What vitamin increases the absorption of Fe?
What mineral suppresses the absorption of Vitamin C?
How long does it take for the retic count to rise in response to Fe therapy? Hb?
Fe = 1 week
Hb = 2 weeks
How long should you continue fe therapy?
Until serum Fe normal
What drug interferes with vit b12 absorption?
What are the causes of megaloblastic macrocytic anemia?
Vit B12 deficiency
What are the causes of non-megaloblastic macrocytic anemia? (4)
What condition are multilobed neutrophils found in? What are these called?
What happens to the reticulocyte count in pernicious anemia?
What disease has high methylmalonic acid and total homocysteine levels? Which has just high homocysteine levels?
Both high = B12
Just homocysteine = folate
How long does it take retic count to increase with B12 administration?
End of first week
How long does the megaloblastic anemia take to correct with B12 supplementation?
What is the general ddx for normocytic anemia?
What are the causes of intrinsic hemolytic anemia? (3)
Enzyme deficiencies (G6PD)
What are the causes of extrinsic hemolytic anemia? (3)
Non-immune (trauma, infx)
What is the test used to identify immune mediated hemolytic anemia?
What is the reticulocyte count like in hemolytic anemia?
What type of anemia is LDH high in?
extrinsic hemolytic anemia
What does an elevated indirect bilirubin indicate? Direct?
Indirect = liver problem
Direct = obstruction
BIte cells on PBS = ?
What are the triggers for G6PD deficiency?
Drugs (antimalarials and sulfa)
What are the two types of drugs that pts with G6PD deficiency should avoid?
What happens to BUN with GI bleeds?
Can increase, but not incredibly sensitive
Itchy after showering = what disease?
What hematological diseases should you be concerned about with skin changes?
What are the secondary causes of polycythemia vera? How can you differentiate this from primary polycythemia vera?
COPD, pulmonary HTN, CHF (lung issues where you need more oxygen carrying capacity)
EPO will be low in primary polycythemia vera