Flashcards in DERM - Introduction to dermatology Deck (31)
what is the atopic triad?
- atopic dermatitis
what are the flat lesions? how are they differentiated?
- macule: under 1 cm
- patch: over 1 cm
what are the raised, solid lesions? how are they differentiated?
- papule: under 1 cm
- nodule: over 1 cm
- tumor: over 2 cm
- plaque: over 1 cm FLAT topped ("plateau")
what are the raised fluild filled lesions? how are the differentiated?
- vesicles: clear fluid, under 1 cm
- bulla: clear fluid, over 1 cm
- pustule: white fluid, filled with pus
are telangiectasias blanchable or non-blanchable?
loss of epidermis, depression in skin, heals WITHOUT scar
flake or plates of skin
what is used to visualize tinea versicolor?
spaghetti and meatballs appearance on woods light - diagnosis?
what is the organism responsible for tinea versicolor?
malassezia furfur is responsible for what condition?
what is the treatment for tinea versicolor?
ketoconazole shampoo, topical antifungals
what is the mechanism of action of topical steroids?
- inhibition of NF-kB, suppressing both B and TC function
- no cytokine transcription
are imidazoles fungistatic or fungicidal?
are allylamines fungistatic or fungicidal?
are polyenes fungistatic or fungicidal?
are allylamines better for dermatophytes or candida?
are polyenes better for dermatophytes or candida?
what is the MOA of the imidazoles?
- inhibit 14-a-demethylase
- stops lanosterol from forming ergosterol
- p450 enzyme inhibitors****
what are the side effects of the imidazoles?
- liver toxicity
- drug interactions
what is the MOA of the allylamines?
inhibit squalene epoxidase
what are the side effects of the allylamines and polyenes?
- taste deficiency
- liver toxicity
what are the first generation antihistamines?
what are the second generation antihistamines?
- fexofenadine (best for itch)
which antihistamine is best for itch?
what is ranitidine used for? what is the MOA?
- H2 blocker
what is the target for psoriasis medication?
inhibition of keratinocyte proliferation
what are the psoriasis meds?
- coal tar
- vitamin D analogs
what are the most specific antibodies for lupus?
- anti dsDNA
- anti smith
what are the common causes of death in lupus patients?
3. renal disease