DERM - Dermatology and systemic disease

Question 1

dermatomyositis affects what groups?

Answer 1

• bimodal age

- women 2x compared to men

Question 2

what is gottrons sign? what disease is it associated with?

Answer 2

• red purple keratotic, atrophic erythema or macules on the extensor surface of finger joints
• dermatomyositis

Question 3

what are the signs of dermatomyositis?

Answer 3

• heliotrope rash
• gottrons sign
• proximal muscle weakness
• elevated serum CK
• muscle pain on grasping
• myogenic changes on electromyography
• anti-Jo antibody test
• nondestructive arthritis, arthralgia

Question 4

what are the systemic effects of dermatomyositis?

Answer 4

• raynaud
• dysphagia
• gastroesophageal reflux
• dysphonia
• AV defects

Question 5

what is the treatment for dermatomyositis?

Answer 5

• muscle: steroids, immunosuppressants

- skin: sun avoidance, sunscreen, topical steroids

Question 6

what is the most common manifestation of systemic LE?

Answer 6

malar rash

Question 7

lupus disease:

• precipitated by UVB exposure
• lesions sharply demarcated and round
• face and scalp most commonly affected

Answer 7

discoid lupus

Question 8

what drugs can cause subacute cutaneous LE?

Answer 8

• HCTZ
• CCBs
• ACEi
• terbinfafine

Question 9

how is diagnosis of SLE made?

Answer 9

blood tests and biopsies of lesional and possibly non-lesional skin

Question 10

what is scleroderma?

Answer 10

disease causing sclerosis of the skin and visceral organs, vasculopathy (raynaud phenomenon) and presence of auto antibodies

Question 11

what are the variants of localized scleroderma?

Answer 11

• morphea
• linear
• en coup de sabre

Question 12

what are the three stages of skin disease (diffuse and CREST) in scleroderma?

Answer 12

• edematous
• indurative or sclerotic
• atrophic

Question 13

what are the components of CREST?**

Answer 13

• Calcinosis: calcium deposits in the skin
• Raynaud phenomenon: spasm of blood vessels in response to cold or stress
• Esophageal dysfunction: acid reflux and decrease in motility of esophagus
• Sclerodactyly: thickening and tightening of the skin on the fingers and hands
• Telangiectasias

Question 14

what is morphea? what disease is it associated with?**

Answer 14

• starts with one to several circumscribed areas of purplish induration
• eventually raised white scar with lilac ring**
• scleroderma

Question 15

reiters sydrome is aka? what condition is it associated with?

Answer 15

• reactive arthritis

- sequelae of GI or GU infection

Question 16

reiters syndrome is associated with what HLA?

Answer 16

B27

Question 17

what is the triad of reiters syndrome?**

Answer 17

• arthritis
• urethritis
• conjunctivitis

Question 18

what is the skin finding in reiters syndrome?

Answer 18

keratoderma blenorrhagicum

Question 19

what are manifestations of T cell lymphoma?

Answer 19

• psoriasis
• atopic dermatitis
• chronic contact dermatitis

Question 20

pagets disease of the breast is thought to arise from ________

Answer 20

ductal carcinoma that migrates to the skin

Question 21

what are the major criteria of sweets syndrome?

Answer 21

• rapid onset of characteristic skin lesions that are tender erythematous plaques and nodules
• typical histopathologic features: dense neutrophil infiltration without leukocytoclastic vasculitis

Question 22

what is the classic triad of hypothyroidism in thyroid disease?

Answer 22

• edematous eyelids

- swollen lower lip and droopy facial appearance

Question 23

• acanthosis nigricans
• diabetic dermopathy
• necrobiosis lipoidica diabeticorum
• granuloma annulare

Answer 23

diabetes

Question 24

what are the 3 signs of psoriatic arthritis?

Answer 24

• current: psoriatic skin or scalp disease
• personal history
• family history: first or second degree relative

Question 25

dactylitis is seen in what condition?

Answer 25

psoriatic arthritis

Question 26

what is the inheritance of peutz jaegher syndromes?

Answer 26

AD

Question 27

what is the inheritance of osler weber rendu?

Answer 27

AD

Question 28

• recurrent spontaneous epistaxis
• multiple mucocutaneous telangiectasias
• visceral AVMs
• first degree relative with HHT

Answer 28

osler weber rendu