Flashcards in DERM - Dermatology and systemic disease Deck (28)
dermatomyositis affects what groups?
- bimodal age
- women 2x compared to men
what is gottrons sign? what disease is it associated with?
- red purple keratotic, atrophic erythema or macules on the extensor surface of finger joints
what are the signs of dermatomyositis?
- heliotrope rash
- gottrons sign
- proximal muscle weakness
- elevated serum CK
- muscle pain on grasping
- myogenic changes on electromyography
- anti-Jo antibody test
- nondestructive arthritis, arthralgia
what are the systemic effects of dermatomyositis?
- gastroesophageal reflux
- AV defects
what is the treatment for dermatomyositis?
- muscle: steroids, immunosuppressants
- skin: sun avoidance, sunscreen, topical steroids
what is the most common manifestation of systemic LE?
- precipitated by UVB exposure
- lesions sharply demarcated and round
- face and scalp most commonly affected
what drugs can cause subacute cutaneous LE?
how is diagnosis of SLE made?
blood tests and biopsies of lesional and possibly non-lesional skin
what is scleroderma?
disease causing sclerosis of the skin and visceral organs, vasculopathy (raynaud phenomenon) and presence of auto antibodies
what are the variants of localized scleroderma?
- en coup de sabre
what are the three stages of skin disease (diffuse and CREST) in scleroderma?
- indurative or sclerotic
what are the components of CREST?****
- Calcinosis: calcium deposits in the skin
- Raynaud phenomenon: spasm of blood vessels in response to cold or stress
- Esophageal dysfunction: acid reflux and decrease in motility of esophagus
- Sclerodactyly: thickening and tightening of the skin on the fingers and hands
what is morphea? what disease is it associated with?****
- starts with one to several circumscribed areas of purplish induration
- eventually raised white scar with lilac ring****
reiters sydrome is aka? what condition is it associated with?
- reactive arthritis
- sequelae of GI or GU infection
reiters syndrome is associated with what HLA?
what is the triad of reiters syndrome?****
what is the skin finding in reiters syndrome?
what are manifestations of T cell lymphoma?
- atopic dermatitis
- chronic contact dermatitis
pagets disease of the breast is thought to arise from ________
ductal carcinoma that migrates to the skin
what are the major criteria of sweets syndrome?
- rapid onset of characteristic skin lesions that are tender erythematous plaques and nodules
- typical histopathologic features: dense neutrophil infiltration without leukocytoclastic vasculitis
what is the classic triad of hypothyroidism in thyroid disease?
- edematous eyelids
- swollen lower lip and droopy facial appearance
- acanthosis nigricans
- diabetic dermopathy
- necrobiosis lipoidica diabeticorum
- granuloma annulare
what are the 3 signs of psoriatic arthritis?
- current: psoriatic skin or scalp disease
- personal history
- family history: first or second degree relative
dactylitis is seen in what condition?
what is the inheritance of peutz jaegher syndromes?
what is the inheritance of osler weber rendu?