DERM - Dermatology and systemic disease Flashcards Preview

Year 2 Specialty Medicine > DERM - Dermatology and systemic disease > Flashcards

Flashcards in DERM - Dermatology and systemic disease Deck (28):
1

dermatomyositis affects what groups?

- bimodal age
- women 2x compared to men

2

what is gottrons sign? what disease is it associated with?

- red purple keratotic, atrophic erythema or macules on the extensor surface of finger joints

- dermatomyositis

3

what are the signs of dermatomyositis?

- heliotrope rash
- gottrons sign
- proximal muscle weakness
- elevated serum CK
- muscle pain on grasping
- myogenic changes on electromyography
- anti-Jo antibody test
- nondestructive arthritis, arthralgia

4

what are the systemic effects of dermatomyositis?

- raynaud
- dysphagia
- gastroesophageal reflux
- dysphonia
- AV defects

5

what is the treatment for dermatomyositis?

- muscle: steroids, immunosuppressants
- skin: sun avoidance, sunscreen, topical steroids

6

what is the most common manifestation of systemic LE?

malar rash

7

lupus disease:

- precipitated by UVB exposure
- lesions sharply demarcated and round
- face and scalp most commonly affected

discoid lupus

8

what drugs can cause subacute cutaneous LE?

- HCTZ
- CCBs
- ACEi
- terbinfafine

9

how is diagnosis of SLE made?

blood tests and biopsies of lesional and possibly non-lesional skin

10

what is scleroderma?

disease causing sclerosis of the skin and visceral organs, vasculopathy (raynaud phenomenon) and presence of auto antibodies

11

what are the variants of localized scleroderma?

- morphea
- linear
- en coup de sabre

12

what are the three stages of skin disease (diffuse and CREST) in scleroderma?

- edematous
- indurative or sclerotic
- atrophic

13

what are the components of CREST?****

- Calcinosis: calcium deposits in the skin
- Raynaud phenomenon: spasm of blood vessels in response to cold or stress
- Esophageal dysfunction: acid reflux and decrease in motility of esophagus
- Sclerodactyly: thickening and tightening of the skin on the fingers and hands
- Telangiectasias

14

what is morphea? what disease is it associated with?****

- starts with one to several circumscribed areas of purplish induration
- eventually raised white scar with lilac ring****

- scleroderma

15

reiters sydrome is aka? what condition is it associated with?

- reactive arthritis
- sequelae of GI or GU infection

16

reiters syndrome is associated with what HLA?

B27

17

what is the triad of reiters syndrome?****

- arthritis
- urethritis
- conjunctivitis

18

what is the skin finding in reiters syndrome?

keratoderma blenorrhagicum

19

what are manifestations of T cell lymphoma?

- psoriasis
- atopic dermatitis
- chronic contact dermatitis

20

pagets disease of the breast is thought to arise from ________

ductal carcinoma that migrates to the skin

21

what are the major criteria of sweets syndrome?

- rapid onset of characteristic skin lesions that are tender erythematous plaques and nodules
- typical histopathologic features: dense neutrophil infiltration without leukocytoclastic vasculitis

22

what is the classic triad of hypothyroidism in thyroid disease?

- edematous eyelids
- swollen lower lip and droopy facial appearance

23

- acanthosis nigricans
- diabetic dermopathy
- necrobiosis lipoidica diabeticorum
- granuloma annulare

diabetes

24

what are the 3 signs of psoriatic arthritis?

- current: psoriatic skin or scalp disease
- personal history
- family history: first or second degree relative

25

dactylitis is seen in what condition?

psoriatic arthritis

26

what is the inheritance of peutz jaegher syndromes?

AD

27

what is the inheritance of osler weber rendu?

AD

28

- recurrent spontaneous epistaxis
- multiple mucocutaneous telangiectasias
- visceral AVMs
- first degree relative with HHT

osler weber rendu