DERM - Injury, allergy, atopy Flashcards Preview

Year 2 Specialty Medicine > DERM - Injury, allergy, atopy > Flashcards

Flashcards in DERM - Injury, allergy, atopy Deck (18):
1

Final strength for remodeling / maturation of a would takes how long?

12 weeks

2

definition: atopic dermatitis

chronic, pruritic, inflammatory skin disease with a wide range of severity

3

what differentiates atopic dermatitis from psoriasis?

- atopic dermatitis: flexural surfaces
- psoriasis: extensor surfaces

4

what is the atopic triad?

- asthma
- atopic dermatitis
- allergic rhinitis

5

what is samter's triad?

- aspirin
- asthma
- atopy

6

what are the 4 main components of atopic dermatitis treatment?

- anti inflammatory
- antibacterial
- moisturizer
- anti-pruritic

7

what links atopy to asthma?

filaggrin

8

what is the cardinal symptoms of urticaria?

itch

9

how does angioedema differ from urticaria?

angioedema can be caused by the same pathogenic mechanisms as urticaria, but the pathology is in the deep dermis and subcutaneous tissue and swelling is the major manifestation

10

what is the major effector cell in urticaria?

mast cell

11

what is immunologic (IgE dependent) urticaria?

- antigen binds to IgE on mast cell surface causing degranulation, which results in release of histamine

- histamine binds to H1 and H2 receptors to cause arteriolar dilation, venous constriction and increased capillary permeability

12

what is non-immunologic (IgE independent) urticaria?

- not dependent on binding of IgE receptors

- e.g. aspirin, physical stimuli, dermagraphism, NSAIDs, morphine (direct histamine releaser)

13

does samter's triad cause IgE dependent or independent urticaria?

independent

14

what is the first line treatment for acute and chronic urticaria?

oral H1 antihistamines (1st generation LESS well tolerated)

15

what is the first line therapy for anaphylaxis?

- EPI
- IV fluids
- oxygen

16

hereditary angioedema is due to ___________ and the inheritance is ____________

- C1 inhibitor deficiency
- AD

17

is angioedema responsive to anaphylaxis treatment?

no

18

TEN / SJS is ___________ (systemic / local) and forms __________ (lesion type)

- systemic
- bullae