DERM - Basal and squamous cell carcinoma Flashcards Preview

Year 2 Specialty Medicine > DERM - Basal and squamous cell carcinoma > Flashcards

Flashcards in DERM - Basal and squamous cell carcinoma Deck (25):
1

pearly papules often containing prominent, dilated subepidermal blood vessels (telangiectasias) - diagnosis?

BCC

2

what is the treatment for BCC?

- excision / destruction

3

BCC can take on what forms?

- rolled borders with ulceration and telangiectasias
- nodular
- morpheaform (scar-like, aggressive)

4

what is the histology for BCC?

- blue islands in dermis usually attached to epidermis
- peripheral palisading
- stromal retraction

5

histology:

- blue islands in dermis usually attached to epidermis
- peripheral palisading
- stromal retraction

BCC

6

what is the familial form of BCC? what is the inheritance?

- gorlin syndrome
- AD

7

what is the pathogenesis of gorlin syndrome?

- mutation of PTCH gene on chromosome 9
- PTCH is a tumor suppressor - mutation allows SHH signaling pathway to stimulate cell growth

8

can immunosuppression lead to BCC or SCC?

SCC

9

SCC often arises in association with what other condition?

actinic keratoses

10

what is a marjolin ulcer?

SCC in site of previous burn

11

terminology: SCC in site of pervious burn

marjolin ulcer

12

risk of SCC metastasis increases with what 4 factors?

- size over FOUR (4) cm
- depth of invasion
- neurotropism
- acantholytic pattern

13

RAPIDLY DEVELOPING flesh colored dome shaped nodules with a central, keratin filled plug imparting a CRATER LIKE TOPOGRAPHY

- sun exposed area
- older people
- rapidly forming

keratoacanthoma

14

actinic keratosis displays what type of abnormal growth?

squamous dysplasia

15

bowenoid papulosis is a variant of _______

SCCIS

16

bowenoid papulosis is related to what virus?

HPV

17

multiple small reddish brown papules in anogenital region of a sexually active male?

bowenoid papulosis

18

merkel cell tumors are of what origin?

neuroendocrine

19

sheets of tumor cells completely invading dermis?

merkel cell carcinoma

20

metastatic tumors to the skin come most commonly from what organ in males? females?

- males: lung
- females: breast

21

what is the sister mary joseph nodule?

umbilical nodule related to a visceral malignancy (stomach, pancreas)

22

mammary paget's disease is almost always associated with underlying ___________

mammary ductal carcinoma

23

- pleomorphic spindle cell tumor with increased mitotic activity
- sun exposed area
- elderly
- firm solitary nodule with or without ulceration

AFX (atypical fibroxanthoma)

24

what are the 3 settings for angiosarcoma?

- idiopathic
- lymphedema associated
- post-irradiation

25

what are the 4 types of kaposi sarcoma?

- classic (endemic): distal extremities of mediterranean / Jewish populations
- AIDS related: skin and mucosal surfaces
- immunosuppression related
- african sub saharan