Derm path I Flashcards Preview

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Flashcards in Derm path I Deck (51)
1

excoriation

traumatic lesion breaking epidermis causing scratch
self induced

2

lichenification

thick and rough skin
repeated rubbing causes it

3

what is a macule and patch

macule is 5 mm
circumscribed flat lesion distinguished from surrounding skin by color

4

what is a papule/ nodule

elevated dome shaped or flat topped lesion
papule 5mm

5

what is a plaque

elevated flat topped lesion
usually greater than 5 mm

6

what is a pustule

discrete pus filled raised lesion

7

what is a scale

dry horny platelike excrescence
usually from imperfect cornification

8

what is a blister
vesicle
bulla

any fluid filled raised lesion
vesicle 5mm

9

what is a wheal

itchy transient elevated lesion with variable blanching and erythema formed as result of dermal edema

10

acantholysis

loss of intercellular cohesion between keratinocytes

11

acanthosis

diffuse epidermal hyperplasia

12

dyskeratosis

abnormal premature keratinization within cells below the stratum granulosum

13

erosion

discontinuity of skin showing incomplete loss of epidermis

14

what is exocytosis

infiltration of the epidermis by inflammatory cells

15

hydropic swelling

intracellular edema of keratinocytes
often seen in viral infections

16

what is hypergranulosis

hyperplasia stratum grnaulosum from intesnse rubbing

17

what is hyperkeratosis

thickening of stratum corneum
assoc with qualitative abnormality of the keratin

18

lentiginous

linear pattern of melanocyte proliferation within epidermal basal cell layer

19

what is papillomatosis

surface elevation caused by hyperplasia and enlargement of contiguous dermal papillae

20

parakeratosis

keratinization with retained nuclei in stratum corneum

21

spongiosis

intercellular edema of the epidermis

22

ulceration

discontinuity of the skin whoing complete loss of epidermis revealing dermis or subcutis

23

vacuoliation

formation of vacuoles within or adjacent to cells
refers to basal cell BM zone area

24

what are fibroepithelial polyps

skin tags
acrochordon
fibroma molle
squamous papilloma

25

fibroepithelial polyps are assoc with what

areas of rubbing by clothing (collar of neck or groin)

26

other names for epithelial inclusion cyst

epithelial cyst
follicular cyst
wen

27

where do epithelial inclusion cysts occur

face, scalp and upper trunk where there are lots of hair follicles

28

cause of epithelial inclusion cysts

obstruction hair follicle above infundibulum near where hair shaft extends beyond skin surface

29

micro epithelial inclusion cyst

filled with keratinous debris and lined by squamous epithelium with granular cell layer

30

what occurs if epithelial inclusion cyst ruptures

provoke chronic inflammatory reaction with granuloma elicited by the extravasted keratin
(foreign body giant cell reaction

31

cause of seborrheic keratosis

proliferation of epidermal basal cells

32

where does seborrheic keratosis appear

non sun exposed skin like trunk and proximal extremities, lateral neck

33

seborrheic keratosis can mimic what skin condition

malignant melanoma

34

postage stamp appearance

seborrheic keratosis

35

leser trelat

acute onset of seborrheic keratosis with malignancies (GI mostly)

36

mutation in seborrheic keratosis

fibroblast growth factor R 3

37

what is acanthosis nigricans

hyperpigmentation flexural regions: axilla, skin folds of neck, groin and anogenital regions

38

acanthosis nigricans is hyperplasia of what

epidermal stratum spinosum

39

acanthosis nigricans in childhood is most likely what

benign

40

acanthosis nigricans acute onset in adult, need to look for what

underly malignant adenocarcinoma because these stimulate epidermis to undergo epidermal hyperplasia

41

what do the benign adnexal neoplasms look like

symmetrical
small
superficial
vertical in orientation

42

characteristics malignant adnexal tumors

asymmetrical large deep and wide

43

what are the types of malignant adnexal tumors

sebaceous carcinoma
eccrine carcinoma
apocrine carcinoma

44

most common type malignant adnexal tumor

sebaceous carcinoma

45

trichoepithleiomas, trichofolliculoma, tricholemmoma and pilomatricoma all involve what

hair follicle

46

what syndrome has multiple tricholemmomas with dominant inheritance

cowden syndrome

47

sebaceous adenoma and sebaceous epithelioma involve what

sebaceous gland

48

Muir Torre syndrome

sebaceous adenomas with association colorectal malignancy (lynch)

49

syringoma, cylindroma, poroma involve what area of body

eccrine glands

50

What is turban tumor

massive confluent cylindromas

51

buds of basaloid cells that resemble primitive hair follicules

trichoepithelioma