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Flashcards in MSK path II Deck (52)
1

What is most common form paraneopkastic caused neuropathy

sensorimotor neuronopathy

2

paraneoplastic sensorimotor neuronopathy is most commonly assoc with what tumor

SCC, oat cell of lung

3

What tumors secrete IgM that could demyelinate nerves

waldenstrom macroglobulinemia

4

what other condition secretes Ig that could damage nerves

multiple myeloma

5

where are SCC located inlungs typically

central

6

perinuclear clearing

waldenstrom macroglobulinemia

7

what is it called when hurts between 2nd and 3rd digit toes

morton neuroma
traumatic nerve injury

8

What is name for hereditary motor and sensory neuropathie

charcot-marie-tooth disease

9

most common inherited peripheral neuropathy

CMT

10

clincal signs CMT

distal mm atrophy
sensory loss-- lots of bruises and scrapes
foot deformities-- pes cavus foot

11

damage to schwanna cells is called

demyelinating neuropathy

12

damage to axons is called what

axonal neuropathy

13

damage to central neurons is called what

neuronopathy

14

painless weakness in eyes

myasthenia gravis

15

autoAb in myasthenia

Ab against ACh R

16

what tumor is myasthenia assoc with

thymoma

17

hassels corpuscles

thymic gland

18

young myasthenic patient with thyroid abrnomality

thymic hyperplasia> thymoma

19

presentation myasthenia patient with Ab against muscle specific R tyrosine kinase

focal muscle involvement
neck, shoulder, facial, respiratory and bulbar

20

Dx myasthenia

Hx
PE
autoAb
electrophysiologic studies

21

Tx myasthenia

ACHE Inhibitors

22

Tx thymoma in myasthenia patient

thymectomy

23

Lambert Eaton Myasthenic Syndrome

autoimmune caused by Ab that block Ach release by inhibiting presynaptic Ca channel

24

clinical difference myasthenia gravis and LEMS

LEMS gets better with time
myasthenia gets worse with time

25

why does LEMS get better with time

because more stimulation will get enough Ca out to cause action

26

LEMS assocaited with

neuroendocrine carcinoma of lung-- looks like ALL in child
usually SCC

27

what microbe produces botulinum toxin

clostridium botulinum
gram +

28

curare

blcok ACh R and cause flaccid paralysis

29

Sx botulism

double vision, blurred vision, droopy eyelids
slurred speech
difficulty swallowing
dry mouth
muscle weakness

30

genetic defects in NMJ lead to what

congenital myasthenic syndromes

31

characteristics of type I skel mm fibers

slow, high lipid content, red color from myoglobin,
high oxidative capacity (low glycolytic)

32

checkerboard pattern of skel mm fibers. darker are what type

II

33

clusters of atrophic muscle fibers

neurogenic

34

perifascicular atrophy in muscle fibers

dermatomyositis

35

type II mm fiber atrophy
normal type I fibers

prolonged corticosteroid therapy or disuse

36

disorders skel muscle happen how

myopathic injury or disrupting the muscle innervation

37

increased CK MM in blood

degeneration releasing cytoplasmic enzymes (part of myofiber necrosis)
segmental myofiber degeneration and regneration

38

when is myofiber hypertophy seen

physiologic adaptation to exercise or in assoc with chronic myopathic conditions

39

cytoplasmic inclusions in mm

vacuoles, aggregates protesins, clustered organelles
all suggest myopathy

40

3 main primary inflammatory myopathies

polymyositis, dermatomyositis and inclusion body myositis

41

what immune mediated disorders can cause myositis

SLE, systemic sclerosis, sarcoidosis

42

muscle fiber surrounded by blue cells

lymphocytes = inflammatory myopathy

43

dermatomyositis

systemic autoimmune disease presents with proximal muscle weakness and skin changes (swollen hands and feet)

44

what occurs in dermatomyositis that leads to muscle injury

vasculitis small vessels

45

anti Mi2 Ab

Gottron papules and heliotrope rash, dermatomyositis

46

anti Jo1 Ab

interstitial lung disease, nonerosive arthritis and skin rash called "mechanics hands"
Ab against histidyl t-RNA synthetase

47

anti P155/P140 Ab

against transcriptional regulators
assoc with paraneoplastic and juvenile dermatomyositis

48

myofiber atrophy accentuated at edges of fascicles

perifascicular atrophy

49

infiltrate rich in CD4 and C'5-9 in muscle fascicles

dermatomyositis

50

what movements are hardest in begining of dermatomyositis

getting up from chair and climbing because affect proximal muscles first

51

heliotrope rash

lilac colored discoloration of upper eyelids with periorbital edema and scaling erythematous eruption dusky red patches over knucles, elbows and knees (gottron papules)

52

associated conditions with dermatomyositis

dysphagia from esophageal mm
interstitial lung disease which can lead to death