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Flashcards in MSK path I Deck (50)
1

how do we measure actin and myosin

Creatinine kinase

2

mutations of myelin protein 0, peripheral myelin22 and periaxin

Charcot-Marie-Tooth disease

3

new nerves that were once destroyed have what different

shorter and thinner myelin

4

histo degenerating myelin

vaucoles

5

what is needed to regrow a nerve

lining by schwann cells/myelin

6

mononeuropathy

single nerve results in deficits in restricted distribution dictated by normal anatomy

7

common causes of mononeuropathy

trauma, entrapment and infections

8

polyneuropathies

involvement of many nerves usually symmetrically

9

characteristic pattern of polyneuropathy

ascending. stocking pattern

10

mononeuritis multiplex

disease that damages several nerves in haphazard fashion
right wrist drop from involved radial nerve and left foot drop from peroneal nerve damage

11

common cause of mononeuritis multiplex

vasculitis

12

polyradiculoneuropathies

affect nerve roots as well as peripheral nerves leading to diffuse symmetric Sx in proximal and distal parts of body

13

what are the inflammatroy neuropathies

gullain barre syndrome
chronic inflammatory demyelinating poly(radiculo)neuropathy
neuropathy associated with systemic autoimmune diseases
neuropathy associated with vasculitis

14

guillain barre is preceded by what most of the time

acute influenza like illness

15

which bacteria have been assoc with guillain barre

campylobacter, CMV,epstein barr, mycoplasma pneumonia, prior vaccination

16

clinical picture of guillain barre

ascending paralysis and areflexia

17

What do you check for on PE for guillain barre

loss of DTR and loss of pain sensation

18

nerve conduction study on guillain barre will show what

slowed because destruction of myelin segments

19

CSF protein levels in guillain barre

elevated from inflammation and altered permeability of microciruclation with spinal roots across subarachniod space

20

what cells are present on nerve Bx of guillain barre

lymphocytes

21

symmetrical sensorimotor polyneuropathy that persists for 2+ months

chronic inflamatory demyelinating polyradiculoneuropathy

22

onion bulb demyelinating

chronic inflammatory demyelinating polyneuropathy

23

what autoimmune diseases can be asssocaited with peripheral neuropathies

RA, sjogren, SLE

24

what type of inflammation can lead to neuopathy

vasculitis

25

what is polyarteritis nodosum

noninfectious inflammation of blood vessls that invovles peripheral nerves

26

fibrinoid necrosis with many eosinophils is associated with what process

vasculitis

27

what infections can cause neuropathies

leprosy
HIV
diptheria
lymes
varicella

28

black nodules on skin

kaposi sarcroma, HIV

29

pseudomembrane in mouth

diptheria

30

blisters in dermatome pattern

shingles, varicella zoster

31

most common cause peripheral neuropathy

DM

32

renal vasculitis assoc with DM

gomerulosclerosis

33

presentation DM polyneuropathy

sensory Sx: numbness, loss of pain sensation, difficulty with balance, paresthesias, dysthesiasj

34

neuropathy in DM patient at risk for

foot and ankle fractures and chronic skin ulcers, which can lead to amputations

35

DM autonomic neuropathy

postural hypotension
incomplete emptying o bladder
sexual dysfunction

36

common cc in DM autonomic neuropathy

sexual dysfunction, seeking viagra

37

uremic neuropathy

distal symmetric neutopathy from axonal degeneration and secondary demyelinations

38

presentation uremic neuropathy

muscle cramps, distal dysthesias, diminished DTRs
in renal failure

39

hypothyroidism can cause what neuropathies

compression mononeuropathies like carpal tunnel or sita symmetric sensory polyneuropathy

40

hyperthyroidism can cause what neuropathy

resembles guillain barre

41

Vit B12 deficiency neuropathy

subacute combined degereation with damage to long tracts in spinal cord, and peripheral nerves

42

What vitamine deficiencies have been associated with peripheral neuropathy

B1(thiamine) B6 (pyridoxine), folate, Vit E, copper and zinc

43

patient has renal failure and white dry skin all around mouth, what is this called

uremic frost

44

cystic degeneration with hemorrhage in alcoholic's brain can be from what deficiency

B1 thiamine

45

What biologic toxins or therapeutic drugs can cause peripheral neuropathies

chemo drugs like vinca alkaloids and taxans
cisplatin-neuronopathy
microtubule inhibitors
alcohol, heave metals

46

what heavy metals can cause neuropathies

lead, mercury, arsenic and thalium

47

basophilic stipling in PBS

lead poisoning

48

black on hands, toxin?

arsenic

49

what malignancies can lead to neuropathies

direct compression of nerve
paraneoplastic
monoclonal gammopathies that can demyelinate

50

what tumor in apex of lung is known to cause compression of peripheral nn

pancoast