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Flashcards in Derm path III Deck (45)
1

ABCD melanoma

asymmetry
border irregularity
color variation
diameter

2

melanoma survival depends on what

stage
mets to lymph nodes

3

mortality of malignant melanoma is graded how

thickeness of melanoma

4

if melanoma is 4mm

92%
80%
50%

5

solar lentigo

focal autonomous overproduction of melanosomes with resultant sustained increase in melanin in kertinocytes

6

what is solar elastosis

permanent incremental damage to reticular collagen with loss of texture and wrinkling

7

what is actinic keratosis

neoplastic proliferation of keratinocytes that have no yet involved the full epidermal thickness
characterized by increased keratin production (scaling) and underlying dermal increase in vascularity (redness)

8

where does actinic keratosis occur

sun-exposed areas of scalp, face, dorsum forearms and hands

9

other names for actinic keratosis

solar keratosis
senile keratosis
keratinocytic intraepithelial neoplasia

10

appearance actinic keratosis

erythematous reddish brown macules or minimally elevated papules with overlying scales

11

size of lesions of actinic keratosis

mm to cm

12

SCC

malignant proliferation epidermal keratinocytes potential for mets to regional lymph nodes or distant sites

13

What is SCC in situ

bowden disease

14

most carcinogenic UV type

UV B wavelengths 280-340

15

other causes of sCC beside UV B

HPV
chornic ulcers and draining fistulous tracts
burns and radiation
chemical exposures

16

CA from chimeny sweeping tar

scrotal CA

17

what genetic syndromes increase chance SCC

epidermodysplasia verruciformis( predisposition to HPC infections and HPV subtypes 5 and 8)
Xeroderma pigmentosa (nucleotide excision repair pathway defects)

18

second most common cutaneous malignancy in US

SCC

19

early apperance invasive SCC

small firm skin colored or erythematous nodule with indistince borders

20

what is surface of SCC

smooth, verrucous or papillomatous

21

appearance of older SCC

large, invasive and central area of tumor on skin can be ulcerated

22

keratoacanthoma

rapidly growing neoplasm on sun exposed areas of older adults

23

common outcome keratoacanthoma

spontaneously clears in 3-4 months

24

another term for keratoacanthoma

SCC keratoacanthoma type

25

basal cell carcinoma

several types of skin neoplasm originating from basal regenerative epithelium of erpidermis that almost never metastazies

26

types of BCC

nodular and sclerosins

27

etiology BCC

increased sunlight exposure in childhood and adolescence, chronic exposure during adulthood

28

What is Gorlin Syndrome

nevoid basal cell carcinoma syndrome
auto dominant

29

appearance of gorlin syndrome

multiple BCC before age 20
pits of palms and soles
odontogenic keratocysts
medulloblastomas
ovarian fibromas

30

msot common cutaneous neoplasm

BCC

31

what is rodent ulcer

advanced presentation of basal cell carcinoma

32

nodular type BCC

traditional
dome shaped, pearly papule or nodule
prominent surface, dilated dermal vessels

33

what will histo of nodular BCC look like

isolated nests of basaloid cells within papillary dermis
nests separated from adjacent stroma by clefts (clear spaces)

34

rodent ulcer type BCC

sclerosing
yellowish white or pearly white
indurated plaque that may retract below plane of skin surface
poorly defined margins
difficult to excise, high recurrence rate

35

apperarance of superficial BCC

multifocal erythematous scaly plaque with rolled edenes
non sun exposed areas
dermal epidermal junction growth pattern
easily excised

36

what is dermatofibrosarcoma protuberans

malignant superficial fibroblastic neoplasm
locall aggressive, rarely mets

37

bednar tumor

pigmented variant dermatofibrosarcoma protuberans

38

mutation in dermatofibrosarcoma protuberans

translocation COL1A1 and PDGFB

39

"storiform" alignment of spindled cells

dermatofibrosarcoma protuberans

40

what type of neoplasm can mycosis fungoides cause

CD4 T cell lymphoma of skin
CLA CCR4 CCR10

41

prognosis mycosis fungoides

8-9 years

42

phases of mycosis fungoides

inflammatory erythrodermic pre-mycotic patch
plaque
tumor

43

what is sezary syndrome

variant in which skin involvement manifest as generalized exfoliative erythroderma

44

nuclei in sezary syndrome

cerebriform nuclei

45

what is mastocytosis

oivoid cells with centrally located nuclei
metachromatic granules in cytoplasm of mast cells