Derm path V Flashcards Preview

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Flashcards in Derm path V Deck (47)
1

what are the autoAb in pemphigus vulgaris and cause what type of blisters

Dsg1 Dsg3 desmosomes
cause suprabasal epidermis blisters

2

what are the autoAb in pemphigus foliaceus

Dsg1 causing subcorneal blisters

3

autoAb in bullous phemphigoid

bind BPAG2, component of hemidesmosomes leading to blisters at lamina lucida of BM

4

where does bullous pemphigoid occur

inner aspects of thighs, flexor surfaces of arms and axilla( areas prone to rubbing)

5

what type of blisters are bullous pemphigoid

subepidermal

6

dermatitis herpetiformois

IgA to gliadin attacks reticulin in dermal papillae fibrils

7

assocations with dermatitis herpetiformis

celiac disease, sprue,
anti gliadin Ab cross react with reticulin in anchoring fibrils

8

clincal presentation of dermatitis herpetiformis

pruritic plaques and vesicles on extensor surfaces, elbows, knees, upper back and buttocks

9

what is panniculitis

inflammation of subcut fatty tissue
septal and lobular

10

erythema nodosum

acute septal inflammation assoc with infection by many agents

11

what can cause erythema nodosum

beta strep
TB
sarcoidosis
IBD
malignancies
sulfonamides
oral contraceptiv es

12

what can cause erythema induratum

uncommon lobular panniculitis of unknown etiology

13

what is weber christian disease

relapsing febrile nodular panniculitis in children and adults

14

what is factitial panniculitis

self induced lobular from traumatic injury and infections

15

what type of panniculitis can present in lupus

lobular

16

what causes verruca vulgaris

HPV
cutaneous 2 and 4
anogenital 6 and 11

17

what do the warts in verruca vulgaris look like

gray-white papules
cobble stone and firm to palpation

18

condyloma plantaris

verruca vulgaris on soles of feet and palms on hand

19

condyloma acuminatum

anogenital with cauliflower appearance

20

keratohyaline granules in epithlial hyperplasia

verruca vulgaris

21

what causes molluscum contagiosum

pox virus

22

clinical presentation molluscum contagiosum

.2-.4 cm nodules on face, trunk and anogenital area
spread by direct contact

23

ellipsoid cytoplasmic inclusions

molluscum bodies

24

what is acne vulgaris

chronic infection of hair follicle by lipase producing propionibacterium acnes

25

Tx for P acnes
or acne vulgaris

retin A with antibiotics like minocycline

26

causes of impetigo

staph and strep

27

types of impetifo

bullosa and contagiosa

28

how does staph cause impetigo

toxins cleave desmoglein 1
localized to stratum corneum
honey colored crust

29

Tx impetigo

anti bacterial soap and topical antibiotic

30

what causes superficial fungal infections

dermatophyte

31

superficial fungi cause infection where

confined to stratum corneum of epidermis
thrive in keratin layer

32

what are predisposing conditions for supergiical fungi

high moisture content
lack exposure to sunlight
increased temp of skin

33

onychomycosis

fungal infection in nail beds

34

tinea versicolor

malassezia furfur
yeast infection causes it

35

what are arthropods

spiders ticks chiggers lice and scabies

36

what are considered insecta

bedbugs
wasps
bees
flies
mosquitoes

37

what bugs cause direct injurious effect

mosquitoes and chiggers

38

what bugs cause acute or delayed HS reaction

bee or wasp

39

what bugs cause direct toxin effect

brown recluse spider

40

what bugs are vectors for what diseases

mosquitoes: malaria, west nile virus, dengue
ticks: lyme disease, RMSF

41

what is ichthyosis

genetic abnormality leading to hyperkeratosis

42

what is epidermolysis bullosa

genetic abnormalities in structural proteins leading to massive bullae

43

porphyrias

auto dominant
defects in heme synthesis
causes urticaria and subepidermal vesicles when exposed to sun

44

simplex type epidermolysis bullosa

keratin 14 5 mutation leads to suprabasalar lesion

45

what porphyrias cause acute neurovisceral with GI and neural Sx

acute intermittent
aminolevulnic acid dehydratase deficient

46

what porphyrias cause acute neurovisceral with curatnous problems

variegate and hereditary coproporphyria

47

what porphyrias cause non acute (cutaneous with light induced lesions)

congenital erythropoetic
erythropoeitic
x linked protoporphyria
cutanea tarda-- assoc with hypertrichosis
urine can be red or dark with light exposure