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Flashcards in MSK path VII Deck (47)
1

what are the most likely cartilage forming tumors ages 10-30

chondroblastoma and chondromyxoid fibroma

2

what cartilage forming tumor is more common in older patients >25 y.o

clear cell chondrosarcoma

3

what is osteochondroma

exostosis
benign cartilage capped tumor attached to skeleton by stalk

4

msot common benign bone tumor

osteochondroma

5

what makes cap of osteochondroma

hyaline cartilage

6

are osteochondromas lytic lesions

no

7

clinical course osteochondroma

stop growing at time of growth plate closure

8

Symptomatic tumor Tx osteochondroma

excision

9

when can osteochondromas progress to chondrosarcomas

in those with multiple hereditary exostosis

10

chondromas

benign tumors of hyaline cartialge
enchondral region of bone

11

what is name of chondroma arising in medullary cavity

enchondroma

12

what are chondromas called that arise on surface of bone

juxtacortical chondromas

13

most common intraosseous cartilage tumor

enchondromas

14

presentation enchondroma

solitary metaphyseal lesion of tubular bones of hands and feet

15

radiograph of chondroma

circumscribe lucencies with central irregular calcifications

16

nonhereditary disorders with multiple enchondromas

ollier disease and Maffucci syndrome

17

how is Maffucci syndrome distinguished

spindle cell hemangioma

18

morphology enchondroma

< 3cm
gray blue and translucent
well circumscribe nodules of hyalin with benign chondrocytes

19

get ollier disease and maffucci syndrome enchondromas mixed with what

chondrosarcomas

20

casing of enchondroma

thin layer reactive bone

21

Maffucci syndrome patients at risk of developing what

ovarian carcinomas and brain gliomas

22

chondrosarcoma

maligant tumor that produces cartilage

23

subclassifications chondrosarcomas

conventional (produce hyaline)
clear cell
de differentiated
mesenchymal

24

age of chondrosarcoma

>40 y.o

25

where do chondrosarcomas arise

axial skeleton, pelvis, shoulder, ribs

26

XR chondrosarcoma

calcified matrix with foci of flocculent densities

27

presentation chondrosarcoma

painful!
progressively enlarging mass
nodular pattern of cartilage produce scalloping

28

matrix in chondrosarcomas

gelatinous or myxoid, can ooze

29

grade 3 chondrosarcoma

high cellularity extreme pleomorphism with bizarre tumor giant cells and mitoses

30

scalloping of bone on XR and increased Ca 65 y.o

chondrosarcoma

31

prognosis grade 1 chondrosarcoma

5 yr 80-90%

32

where do chondrosarcomas mets to

lungs

33

Tx conventional chondrosarcoma

wide surgical excision

34

Tx mesenchymal and dedifferentiated tumors

excised and Tx with chemo because aggressive

35

Ewing Sarcoma

malignant bone tumor characterized by primitive round cells without obvious differentiation

36

What are in ewing sarcoma family tumors

ewing sarcoma
and primitive neuroectodermal tumor PNET

37

bone tumors with youngest age presentation <20 y.o

ewing sarcoma family tumors

38

where do ewing tumors arise

diaphysis of long tubular bones in medullary cavity

39

clinical presentation ewing sarcomas

pain, tender warm and swollen
sometimes like infection: fever, inc sed rate, anemia, leukocytosis

40

radiograph ewings

destructive lytic lesion with permeative margins that extend into soft tissues

41

onion skin fashion of periosteal reaction

ewing sarcoma

42

translocation in ewing sarcoma

11;22

43

gross morphology ewing sarcoma

soft tan white and hemorrhage and necrosis
sheets of uniform small cells that are larger thatn lymohocytes
little cytoplasm

44

homer wright rosettes (round groupings with central fibrillary core)

neuroectoderm differentiation---- ewings sarcoma

45

rossetting and PAS +

ewings sarcoma

46

Tx ewing like tumors and ewings

neoadjuvant chemo with surgical excision
+/- irradiation

47

prognostic finding for ewings

amount of chemo-induced necrosis