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Flashcards in Derm path IV Deck (51)
1

25 year old with alot of itching and rash that came on suddenly

mast cell dependent and IgE dependent
acute allergic reaction

2

what type of hives is mast cell dependent and IgE independent

drug or other substance that triggers mast cells directly

3

What type of hives is Mast Cell dependent IgE dependent

acute allergic reaction

4

what type of hives is mast cell independent and IgE independent

aspirin induced vasodilation
hereditary angioneurotic edema (C1 inhibitor deficiency)

5

Tx for acute urticaria

antihistamines, subcut epinephrine, IM injections corticosteroids

6

patient with known c1 inhibitor deficiency has acute urticaria, what do you Tx with

C1 inhibitor concentrates, kallikrein inhibitor or fresh frozen plasma

7

what does the rash look like in acute urticaria

wheals that are erythematous edematous circular plaques covered by intact normal epidermal surface
commonly on trunk and extremities

8

blanching means what

erythema fades to white with direct contact-- good.. most likely just urticaria

9

how long does acute urticaria last

24 hours
sometimes days- months

10

what is spongiotic dermatitis

eczema

11

epidermal edema with prominent lymphocytes in dermis and epidermis

eczema

12

clinical sign eczema

acute onset red papulovesicular lesions which may ooze or crust

13

what type of HS is eczema

T cell mediated type IV

14

what is erythema multiforme

HS reaction to drugs, infections, malignancy, collagen vascular disorderts

15

what type of infections can cause erythema multiform

Herpes
deep fungal (histo)
salmonella typhii
leprosy

16

what drugs can cause erythema multiforme

antibiotics
salicylates
anti malerials

17

what is the multiforme pattern

red pale red

18

what is the severe systemic fibrile form of erythema multiforme with mucosal involvement

stevens johnson syndrome

19

what is toxic epidermal necrolysis

form of erythema multiforme with diffuse necrosis and sloughing of skin and mucosae

20

what is seborrheic dermatitis

chronic dermatitis

21

where is seborrheic dermatitis found

scalp forehead and glabella space (upper eybrow)
high density sebaceous glands

22

what infection can cause seborrheic dermatitis

malassezia furfur

23

what is psoriasis

chronic skin condition
affects skin of elbows, knees, scalp, lumbosacral area, intergluteal cleft and glans penis

24

psoriasis is assoc with

arthritis

25

HLA psoriasis

cW 0602
increased CD4 TH1 sensitized cells set off other T cells causing increased cytokines leading to epidermal proliferation

26

typical lesions in psoriasis

well demarcated pink-salmon plaque

27

koebner phenomenon

trauma can induce psoriatic lesions in predisposed people

28

what causes lichen simplex chornicus

chronic rubbing or scratchin

29

nodular lichen simplex chronicus

prurigo nodularis

30

lichen planus

self limiting chornic inflammatory condition of skin and mucous membranes

31

prognosis lichen planus

resolves spontaneously 1-2 years after onset

32

clincal presentation lichen planus

multiple plaques symmetrically distributed on extremities and glans penis
wickham striae appearance

33

sawtoothing and civatte bodies

lichen planus

34

what is discoid lupus erythematous

localized cutaneous manifestations of SLE with no assoc systemic manifestations

35

major cutaneous findings in discoid lupus erythematosus

malar erythema
discoid (coin like) scaling plaques

36

chronic plaques with thinned atrophic epidermis and areas of dilated tortuous dermal vessels

lupus erythematosus

37

central hypopigmentation surrounded by peripheral hyperpigmentation

lupus erythematosus

38

lymphopcytes in superficial and deep dermis
thinned epidermis with loss of rete ridges and hyperkeratosis

lupus errythematosus

39

granular deposits of IgG and C3 at dermoepidermal junction

+"band test"
lupus erythematosus

40

population commonly affected by rosacea

30-60 y.o F

41

stages of rosacea

-pre-rosacea (flushing)
- erythematotelengiectatic
-papulopustular
-phymatous

42

what skin condition has perifollicular inflammation changes similar to acne vulgaris

rosacea

43

what is a common friction lbister

intraepidermal blister usually just beneath stratum granulosum with scant or no inflammation in papillary dermis

44

what are the immune mediated bulla

pemphigus group of diseases
bullous pemphigoid
dermatitis herpetiformis

45

what are the genetic blistering diseases

epidermolysis bullosa- -inherited defects in collagen, laminin leading to several disorders with weak skin and blistering
-porphyrias

46

separation at the dermal epidermal junction is what type of blister

subepidermal

47

in general what are the pemphigus group of diseases

autoimmune skin diseases: IgG autoAb to desmosomes (spinous processes) of squamous epithelial cells

48

what are the 4 clinical and pathologic types of pemphigus diseases

pemphigus vulgaris
pemphigus vegetans
pemphigus foliaceus
pemphibus erythematosis
-paraneoplastic pemphigus

49

what is most common pemphigus disease

pemphigus vulgaris, invovles mucosa and scalp, face, axilla, groin and other pressure points

50

what is pemphigus foliaceus

benign course, involves face, scalp, chest and back, spares mucous membranes
epidemic in south america

51

when do you see paraneoplastic pemphigus

with malignancies (lymphoma)