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Neuro Block 2-RG > Drug Deck > Flashcards

Flashcards in Drug Deck Deck (4)
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1

3 generation cephalosporins (ceftriaxone)
mechanism
spectrum
resistance
side effects

-bind transpeptidases: inhibit cell wall synthesis
-Strep + Gram -
-inactivation by beta-lactamases
-allergy

2

Amphotericin B
mechanism
spectrum
distribution
resistance
side effects

-ergosterol binding
-broad, systemic yeasts and molds
-liposomal, crosses BBB
-rare
-70% nephrotoxicity b/c binds cholesterol

3

Flucytosine
mechanism
spectrum
distribution
resistance
side effects

-antimetabolite in fungi (5-FU)
-yeast (Candida and Cryptococcus)
-oral, penetrates BBB
-to avoid: cotreat w/ amphotericin B
-bone marrow suppression

4

Azoles
mechanism
spectrum
distribution
resistance
side effects

-binds P450 (Erg111) that makes ergosterol
-systemic mycoses and yeast
-orally available, EFFLUX TRANSPORTER SUBSTRATE
-altered P450
-drug-drug, neurotoxicity, hepatotoxicity, hormone synthesis (X pregnancy)