Opioid Analgesics Flashcards Preview

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Flashcards in Opioid Analgesics Deck (15)
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1

Where do opioids act most effectively?

at 1˚-2˚ afferent synapse

2

What is an example of an endogenous opioid?

endorphines, endomorphines

3

What are the three opioid receptor types?

mu
kappa
delta

4

Functions of mu receptor

analgesia
respiratory suppression
decreased GI motility

5

Functions of kappa receptor

analgesia
sedation
decreased GI motility

6

Functions of delta receptor

modulation of mu receptor

7

ORL-1 receptor

structurally similar to mu but insensitive to opioid analgesics

8

What type of receptor are mu, kappa, and delta opioid receptors?

G-protein coupled receptors

9

What are the primary actions of the mu receptor?

K+ channel activation in pre- and postsynaptic neurons
--->prevents depolarization
Ca2+ channel inhibition in presynaptic neurons
--->prevents NT release

10

The release of what NTs is blocked by Ca2+ activation?

glutamate and substance P

11

What receptor types does morphine primarily work on?

mu and kappa

12

Why is heroin faster acting than morphine?

more lipid soluble, crosses BBB more easily

13

What opioid antagonist is used in acute overdoses of opioids?

naloxone

14

What opioid antagonist is used in opioid addiction patients?

naltrexone

15

What are the two types of important opioid metabolites found in circulation?

pharmacologically active
toxic